Sex bias of females in survival from cancer and infections. Is X the answer?

Sex bias of females in survival from cancer and infections. Is X the answer?
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女性在癌症和感染存活率方面的性别偏见。X是答案吗?

DOI:
10.1038/s41416-020-01245-1
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发表时间:
2021-03
影响因子:
8.8
通讯作者:
Hersey P
Hersey P
中科院分区:
医学1区
文献类型:
--
作者:
Emran AA;Gallagher SJ;Tiffen JC;Hersey P

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COVID-19感染的死亡率凸显了传染病和癌症中男性和女性存活率的主要差异。在癌症方面,人们的注意力一直集中在男性和女性X染色体基因表达的差异上,与免疫反应有关的基因在女性中表达的优势。重要的发现是,一些基因是重要的表观遗传调节因子,在免疫反应中起着基本作用。
Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in men and women with a preponderance of genes involved in immune responses being expressed in women. Important findings have been that some of the genes are important epigenetic regulators that play fundamental roles in immune responses.
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