Engineering biological systems using automated biofoundries.

Engineering biological systems using automated biofoundries.
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DOI:
10.1016/j.ymben.2017.06.003
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发表时间:
2017-07
影响因子:
8.4
通讯作者:
Zhao H
Zhao H
中科院分区:
工程技术1区
文献类型:
--
作者:
Chao R;Mishra S;Si T;Zhao H

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基因电路和微生物细胞工厂等工程生物系统有望解决现代社会的许多挑战。然而,研究和开发的手工过程缓慢、昂贵且不一致,是生物技术和生物工程的一个主要障碍。近年来,生物铸造厂或生物铸造厂已被开发用于自动化设计-构建-测试工程周期,以加速这些流程。本综述总结了这些生物制品的使能技术以及它们的早期成功和剩余挑战。
Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
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