Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks.
Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks.
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DOI：
10.1016/j.jad.2017.07.001
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发表时间：
2018-06
影响因子：
6.6
通讯作者：
Trivedi MH
中科院分区：
文献类型：
--
作者：
Gadad BS;Jha MK;Czysz A;Furman JL;Mayes TL;Emslie MP;Trivedi MH
近年来，我们对重度抑郁症（MDD）的病理生理学有了更深入的了解。然而，这种理解的提高并没有转化为治疗结果的改善，因为疾病的特异性生物标志物的鉴定对于促进更快速，成功的治疗仍然是至关重要的。正在进行的研究探讨了使用神经影像学，神经生理学，基因组学，蛋白质组学和代谢组学措施筛选生物标志物的重要性。在本综述中，我们强调了在MDD和治疗反应中差异表达的生物标志物，并特别强调了将继续寻找基于血液的生物标志物的先进技术的最新进展。由于空间限制，我们无法详细介绍所有生物标志物平台，如神经生理学和神经影像学标志物，尽管它们的贡献肯定适用于生物标志物综述，对该领域有价值。尽管对抑郁症和/或治疗结果的可靠生物标志物的研究仍在进行中，但快速扩展的研究领域沿着有前途的新技术可能为确定关键因素提供基础，这些因素最终将有助于指导患者更快，更有效地治疗MDD。
In recent years, we have accomplished a deeper understanding about the pathophysiology of major depressive disorder (MDD). Nevertheless, this improved comprehension has not translated to improved treatment outcome, as identification of specific biologic markers of disease may still be crucial to facilitate a more rapid, successful treatment. Ongoing research explores the importance of screening biomarkers using neuroimaging, neurophysiology, genomics, proteomics, and metabolomics measures. In the present review, we highlight the biomarkers that are differentially expressed in MDD and treatment response and place a particular emphasis on the most recent progress in advancing technology which will continue the search for blood-based biomarkers. Due to space constraints, we are unable to detail all biomarker platforms, such as neurophysiological and neuroimaging markers, although their contributions are certainly applicable to a biomarker review and valuable to the field. Although the search for reliable biomarkers of depression and/or treatment outcome is ongoing, the rapidly-expanding field of research along with promising new technologies may provide the foundation for identifying key factors which will ultimately help direct patients toward a quicker and more effective treatment for MDD.
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影响因子：
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DOI：
10.1017/s1461145711001660
发表时间：
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影响因子：
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作者：
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