Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study.
Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study.
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DOI：
10.1590/1516-4446-2019-0802
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
DelBello MP
中科院分区：
文献类型：
--
作者：
Nery FG;Wilson AR;Schneider MR;Strawn JR;Patino LR;McNamara RK;Adler CM;Strakowski SM;DelBello MP
目的：前瞻性研究双相情感障碍父母的基线临床特征和药物暴露是否能预测其子女的抑郁障碍或双相情感障碍的发展。在这项研究中，对年龄在9-20岁、至少有一位亲生父母患有双相情感障碍且无情绪或精神病病史(n=93)的青少年进行了前瞻性评估和自然化治疗。参与者被分成两组：转换者，定义为在随访期间符合DSM-IV情绪发作标准的人(n=19)；或非转换者(n=74)。Logistic回归模型被用来调查基线临床变量和随访期间的药物暴露以及发生第一次情绪发作(转换)的风险之间的关系。多变量回归分析显示，基线焦虑障碍和亚综合征情绪障碍与随访期间转换的风险增加相关。将药物暴露添加到多变量模型中表明，在随访期间暴露于抗抑郁药与转换风险增加相关。在使用抗抑郁药物治疗患有焦虑和/或新出现的抑郁症状的双相情感障碍子女时应谨慎，因为发展为主要情绪障碍的风险增加。
To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion). Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion. Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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影响因子：
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DOI：
10.1097/00004583-200104000-00014
发表时间：
2001-04-01
影响因子：
13.3
作者：
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