Automatic framework for patient-specific modelling of tumour resection-induced brain shift.
Automatic framework for patient-specific modelling of tumour resection-induced brain shift.
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DOI:
10.1016/j.compbiomed.2022.105271
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发表时间:
2022-04
影响因子:
7.7
通讯作者:
中科院分区:
文献类型:
--
作者:
Our motivation is to enable non-biomechanical engineering specialists to use sophisticated biomechanical models in the clinic to predict tumour resection-induced brain shift, and subsequently know the location of the residual tumour and its boundary. To achieve this goal, we developed a framework for automatically generating and solving patient-specific biomechanical models of the brain. This framework automatically determines patient-specific brain geometry from MRI data, generates patient-specific computational grid, assigns material properties, defines boundary conditions, applies external loads to the anatomical structures, and solves differential equations of nonlinear elasticity using Meshless Total Lagrangian Explicit Dynamics (MTLED) algorithm. We demonstrated the effectiveness and appropriateness of our framework on real clinical cases of tumour resection-induced brain shift.
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影响因子:
4
作者:
通讯作者:
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影响因子:
4.1
作者:
Hu, Jingwen;Jin, Xin;King, Albert I.
通讯作者:
King, Albert I.
影响因子:
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Drakopoulos F;Tsolakis C;Angelopoulos A;Liu Y;Yao C;Kavazidi KR;Foroglou N;Fedorov A;Frisken S;Kikinis R;Golby A;Chrisochoides N
通讯作者:
Chrisochoides N
影响因子:
5.7
作者:
Dale, AM;Fischl, B;Sereno, MI
通讯作者:
Sereno, MI
影响因子:
2.4
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Miller K;Horton A;Joldes GR;Wittek A
通讯作者:
Wittek A