Effects of Betaxolol and Latanoprost on Ocular Blood flow and Visual Fields in Patients with Primary Open-Angle Glaucoma
Effects of Betaxolol and Latanoprost on Ocular Blood flow and Visual Fields in Patients with Primary Open-Angle Glaucoma
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倍他洛尔和拉坦前列素对原发性开角型青光眼患者眼血流和视野的影响
DOI：
10.1177/112067210401400305
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发表时间：
2004
影响因子：
1.7
通讯作者：
C. Göktan
中科院分区：
文献类型：
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作者：
E. Erkin;S. Tarhan;Ö. Kayıkçıoğlu;H. Devecı;C. Güler;C. Göktan
目的采用盲法前瞻性临床研究，评价倍他洛尔和拉坦前列素对原发性开角型青光眼（POAG）患者眼血流和视野的影响。方法32例初治原发性开角型青光眼患者纳入研究。患者随机分为两组。第一组接受0.50%倍他洛尔每日两次治疗，第二组接受0.005%拉坦前列素每日一次治疗。治疗第一个月和第三个月的基线和治疗后检查包括眼内压（IOP）测量、自动视野检查和眼血流评估。对于视野的评价，使用平均缺损和模式标准差指数。通过彩色多普勒成像的视网膜中央动脉（CRA）和颞睫状后短动脉（PCA）的眼血流进行评估。测量每支血管的收缩期峰值（PSV）和舒张末期（EDV）血流速度，并计算阻力指数（RI）。结果排除1例不依从患者后，31例患者31眼完成研究。两种药物均显著降低IOP（p<0.05）。拉坦前列素的平均IOP降低作用显著高于倍他洛尔（p=0.03）。两组视野指数均无显著性变化（p>0.05）。两组CRA或PCA的PSV或EDV测量值均无显著变化（p>0.05）。两种药物均降低CRA和PCA的RI。基线和3个月血流测量值之间的平均变化在倍他洛尔和拉坦前列素之间没有显著差异（p>0.05）。结论：在3个月的治疗期内，倍他洛尔和拉坦前列素都倾向于改善眼部血流量，但没有一种上级另一种。结果表明，倍他洛尔对眼循环的直接（非IOP依赖性）影响优于拉坦前列素。此外，在此期间，两种药物均未引起视野的显著全面改善。
Purpose To evaluate the effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma (POAG) by means of an obseiver-masked, prospective clinical study. METHODS Thirty-two patients with newly diagnosed POAG were included in the study. The patients were randomized into two groups. The first group was treated with betaxolol 0.50% twice daily and the second group with latanoprost 0.005% once daily. Baseline and post-treatment examinations on the first and third months of treatment included intraocular pressure (IOP) measurement, automated visual field testing, and ocular blood flow assessment. For evaluation of visual fields, mean defect and pattern standard deviation indices were used. Ocular blood flow was assessed by means of color Doppler imaging of the central retinal artery (CRA) and the temporal short posterior ciliary artery (PCA). For each vessel, peak systolic (PSV) and end-diastolic (EDV) blood flow velocities were measured and resistivity index (RI) calculated. Results After exclusion of one noncompliant patient, the study was completed with 31 eyes of 31 patients. Both drugs significantly reduced IOP (p<0.05). The mean IOP lowering effect of latanoprost was significantly higher than that of betaxolol (p=0.03). Visual field indices exhibited no significant changes in either group (p>0.05). There were no significant changes in PSV or EDV measurements of CRA or PCA in either group (p>0.05). RI decreased in both CRA and PCA with both drugs. The mean changes between baseline and 3 month blood flow measurements were not significantly different between betaxolol and latanoprost (p>0.05). CONCLUSIONS Over a treatment period of 3 months, both betaxolol and latanoprost tended to improve ocular blood flow without one of them being superior to the other. The results suggest that the direct (non IOP-dependent) influence on ocular circulation is better for betaxolol than for latanoprost. In addition, neither drug caused significant generalized improvements in visual fields during this period.
影响因子：
--
作者：
Heijl, A;Leske, MC;Hussein, M
通讯作者：
Hussein, M
拉坦前列素和噻吗洛尔-XE 对正常眼流体动力学的影响。
影响因子：
4.2
作者：
Sponsel,WE;Mensah,J;Kiel,JW;Remky,A;Trigo,Y;Baca,W;Friberg,T
通讯作者：
Friberg,T