Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice
Dysbiosis of gut microbiota induced the disorder of helper T cells in influenza virus-infected mice
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流感病毒感染小鼠肠道菌群失调导致辅助性T细胞紊乱
DOI：
10.1080/21645515.2015.1009805
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发表时间：
2015-04
影响因子：
4.8
通讯作者：
Chen Xiao-yin
中科院分区：
文献类型：
--
作者：
Yu Bin;Dai Cong-qi;Chen Jia;Deng Li;Wu Xian-lin;Wu Sha;Zhao Chang-lin;Jiang Zhen-you;Chen Xiao-yin
广泛理解的是，肠道微生物群通过与身体免疫力的动态相互作用而有助于维持肠道内稳态。流感疫苗注射后的免疫调节对疫苗的有效性有重要影响，但机体微生物群与疫苗有效性之间的作用机制尚不清楚。单个细菌物种对局部肠粘膜组织以外的全身免疫系统平衡的影响也仍然不太清楚，相关机制仍然未知。在这项研究中，通过施用各种抗生素，我们检查了用流感病毒感染小鼠后小鼠中辅助性T细胞亚群的平衡，然后试图模仿患者在流感季节总是接受抗生素治疗的临床实践。这些数据表明，各组小鼠在辅助性T细胞亚群的组成方面呈现不同的免疫应答，尽管Th17细胞活性似乎不参与对抗生素干预敏感的小鼠的全身免疫调节。Th1、Th2和抗炎调节性T细胞参与了受寄生虫诱导的生态失调影响的全身免疫应答。因此，我们认为肠道植物群具有维持免疫平衡和抑制炎症反应的作用，这可能有助于临床在流感疫苗接种时考虑肠道植物群。
It is widely understood that commensal microbiota contributes to the maintenance of intestinal homeostasis through dynamic interactions with a body's immunity. And the immune regulation is important for the influenza vaccine's effectiveness after body injection, however, the mechanism between commensal microbiota and vaccine's effectiveness remains unknown. The impact that individual bacteria species have on the balance of the systemic immune system beyond the local intestinal mucosal tissues also remains less clear, and the related mechanism is still unknown. In this study, through the administration of various antibiotics, we examined the balance of helper T cell subsets in mice after inoculating them with the influenza virus and then, attempted to imitate the clinical practice in which patients are always prescribed with an antibiotic treatment in flu season. The data indicates that the mice in each group present differential immune responses in terms of the makeup of helper T cell subsets, although the Th17 cell activity seems to not be involved in the systemic immune modulation in the mice that are susceptible to the intervention of antibiotic. Th1, Th2, and anti-inflammatory regulatory T cells have been implicated in the contribution to the systemic immune response influenced by the antibiotic-induced dysbiosis. Thus we believe that the normal intestinal flora could maintain the immune balance and inhibit the inflammatory responses, which may be useful for clinical application to take intestinal flora into consideration when influenza vaccination was used.
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DOI：
10.4049/jimmunol.1301661
发表时间：
2014-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Duluc D;Joo H;Ni L;Yin W;Upchurch K;Li D;Xue Y;Klucar P;Zurawski S;Zurawski G;Oh S
通讯作者：
Oh S
影响因子：
8
作者：
通讯作者：
--
先天和适应性免疫会灵活合作，以维持宿主 - 微生物互助。
DOI：
10.1126/science.1172747
发表时间：
2009-07-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Slack E;Hapfelmeier S;Stecher B;Velykoredko Y;Stoel M;Lawson MA;Geuking MB;Beutler B;Tedder TF;Hardt WD;Bercik P;Verdu EF;McCoy KD;Macpherson AJ
通讯作者：
Macpherson AJ
DOI：
10.1126/science.1183021
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iwasaki A;Medzhitov R
通讯作者：
Medzhitov R
影响因子：
29.7
作者：
Hill DA;Artis D
通讯作者：
Artis D