Segmented filamentous bacteria take the stage.
Segmented filamentous bacteria take the stage.
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作者：
共生菌对粘膜免疫系统的成熟和功能至关重要。然而，人们对这些相互作用的机制知之甚少。此外，微生物群组成的作用以及该群落中单个物种在刺激不同类型免疫中的重要性是主要的未解之谜。我们最近证明肠道中两种主要效应T细胞群（IL-17+ Th17细胞和Foxp3+ Tregs细胞）之间的平衡需要来自共生菌的信号，并依赖于肠道微生物群的组成。比较Th17细胞缺乏和Th17细胞充足小鼠的微生物群，发现分段丝状细菌（SFB）能够在肠道中特异性诱导Th17细胞。SFB是可以扭曲粘膜效应T细胞平衡从而影响个体免疫适应性的共生物种的第一个例子。
Commensal bacteria are crucial for maturation and function of the mucosal immune system. However, the mechanisms of these interactions are poorly understood. In addition, the role of the composition of the microbiota and the importance of individual species in this community in stimulating different types of immunity are major unanswered questions. We recently demonstrated that the balance between two major effector T cell populations in the intestine, IL-17+ Th17 cells and Foxp3+ Tregs, requires signals from commensal bacteria and is dependent on the composition of the intestinal microbiota. Comparison of microbiota from Th17 cell-deficient and Th17 cell-sufficient mice identified segmented filamentous bacteria (SFB) as capable of specifically inducing Th17 cells in the gut. SFB represent the first example of a commensal species that can skew the mucosal effector T cell balance and thus affect the immune fitness of the individual.
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影响因子：
82.9
作者：
Zheng, Yan;Valdez, Patricia A.;Ouyang, Wenjun
通讯作者：
Ouyang, Wenjun
DOI：
10.1073/pnas.0307317101
发表时间：
2004-02-17
影响因子：
11.1
作者：
Suzuki, K;Meek, B;Fagarasan, S
通讯作者：
Fagarasan, S
影响因子：
64.5
作者：
Mazmanian, SK;Liu, CH;Kasper, DL
通讯作者：
Kasper, DL
影响因子：
64.8
作者：
Turnbaugh, Peter J.;Ley, Ruth E.;Gordon, Jeffrey I.
通讯作者：
Gordon, Jeffrey I.
影响因子：
30.3
作者：
Ivanov II;Frutos Rde L;Manel N;Yoshinaga K;Rifkin DB;Sartor RB;Finlay BB;Littman DR
通讯作者：
Littman DR