Association of VLDLR haplotypes with abdominal fat trait in ducks

Association of VLDLR haplotypes with abdominal fat trait in ducks
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鸭 VLDLR 单倍型与腹部脂肪性状的关联

DOI:
10.5194/aab-60-175-2017
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发表时间:
2017-06
影响因子:
1.8
通讯作者:
Zhang TJ
Zhang TJ
中科院分区:
农林科学3区
文献类型:
--
作者:
Pan Shifeng;Wang Cong;Dong Xuan;Chen Mingliang;Xing Hua;Zhang TJ

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抽象的。本研究旨在探讨高邮鸭VLDLR(极低密度脂蛋白受体)基因多态性与体重及腹部脂肪沉积的相关性。试验选用1个纯系高邮鸭267只。通过聚合酶链式反应和DNA测序筛选VLDLR基因的多态性。在 5'-UTR 和信号肽区域中鉴定出四个新的单核苷酸多态性 (SNP)(g.151G > A、g.170C > T、g.206A > G 和 g.278–295del)。此外,基于四个 SNP 鉴定了八个单倍型。 H8 是最常见的单倍型,频率超过 31%。结果表明,这四个 SNP 及其单倍型组合与 6-10 周龄时的体重显着相关(P
Abstract. This study aimed to determine the correlation among VLDLR (very low-density lipoprotein receptor) gene polymorphisms, body weight and abdominal fat deposition of Gaoyou ducks. A total of 267 Gaoyou ducks from one pure line was employed for testing. The polymorphisms of the VLDLR gene were screened by polymerase chain reaction and DNA sequencing. Four novel single nucleotide polymorphisms (SNPs) (g.151G  >  A, g.170C  >  T, g.206A  >  G and g.278–295del) were identified in the 5'-UTR and signal peptide region. Furthermore, eight haplotypes were identified based on the four SNPs. The H8 was the most common haplotype with a frequency of more than 31 %. The four SNPs and their haplotype combinations were shown to be significantly associated with body weight at 6–10 weeks of age (P
DOI: 10.1111/j.1742-4658.2009.07513.x
发表时间: 2010-02
期刊: The FEBS Journal
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作者:
Akira Suwa;M. Yoshino;C. Yamazaki;M. Naitou;Rie Fujikawa;S. Matsumoto;Takeshi Kurama;T. Shimokawa;I. Aramori
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