Multimodal magnetic resonance imaging: The coordinated use of multiple, mutually informative probes to understand brain structure and function.
Multimodal magnetic resonance imaging: The coordinated use of multiple, mutually informative probes to understand brain structure and function.
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DOI：
10.1002/hbm.21440
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发表时间：
2013-02
影响因子：
4.8
通讯作者：
Peterson, Bradley S.
中科院分区：
文献类型：
--
作者：
Hao, Xuejun;Xu, Dongrong;Bansal, Ravi;Dong, Zhengchao;Liu, Jun;Wang, Zhishun;Kangarlu, Alayar;Liu, Feng;Duan, Yunsuo;Shova, Satie;Gerber, Andrew J.;Peterson, Bradley S.
关键词：
不同的成像方式提供了独特的信息渠道，以探测大脑结构或功能组织的不同方面。结合起来，不同的模态提供了关于组织组织的互补和相互信息的数据，而不是它们的总和。我们从20名健康成年人中采集了四种MRI模式-解剖MRI，功能MRI，扩散张量成像（DTI）和磁共振波谱（MRS）-的数据并进行了空间配准，以了解一种模式测量的个体间差异如何解释大脑每个体素的其他模式测量的差异。我们检测到显着的相关性，局部体积与功能激活的幅度，这表明，潜在的局部体积的变化有助于功能激活的个体差异。我们还检测到显着的负相关NAA（神经元密度和活力的推定测量）与额叶皮质中的白色物质的体积、与上级纵束内的组织的基于DTI的测量、以及与简单视觉和运动任务期间的功能激活和默认模式活动的幅度进行比较，表明局部体积、白色物质组织、并且功能激活源自那些区域中神经元的数量或密度的潜在变化。许多这些成像测量与不同脑组织和不同神经系统内的智力能力测量相关，表明智力能力的神经决定因素涉及脑组织组织的许多不同特征，只有当用多种MRI模式对同一个体进行成像时才能有信心地得出结论。
Differing imaging modalities provide unique channels of information to probe differing aspects of the brain’s structural or functional organization. In combination, differing modalities provide complementary and mutually informative data about tissue organization that is more than their sum. We acquired and spatially coregistered data in four MRI modalities – anatomical MRI, functional MRI, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) – from 20 healthy adults to understand how inter-individual variability in measures from one modality account for variability in measures from other modalities at each voxel of the brain. We detected significant correlations of local volumes with the magnitude of functional activation, suggesting that underlying variation in local volumes contributes to individual variability in functional activation. We also detected significant inverse correlations of NAA (a putative measure of neuronal density and viability) with volumes of white matter in the frontal cortex, with DTI-based measures of tissue organization within the superior longitudinal fasciculus, and with the magnitude of functional activation and default-mode activity during simple visual and motor tasks, indicating that substantial variance in local volumes, white matter organization, and functional activation derives from an underlying variability in the number or density of neurons in those regions. Many of these imaging measures correlated with measures of intellectual ability within differing brain tissues and differing neural systems, demonstrating that the neural determinants of intellectual capacity involve numerous and disparate features of brain tissue organization, a conclusion that could be made with confidence only when imaging the same individuals with multiple MRI modalities.
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影响因子：
2.5
作者：
Gore, JC;Horovitz, SG;Skudlarski, P
通讯作者：
Skudlarski, P
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Devlin JT;Sillery EL;Hall DA;Hobden P;Behrens TE;Nunes RG;Clare S;Matthews PM;Moore DR;Johansen-Berg H
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MILLER, MI
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3.3
作者：
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通讯作者：
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