Regional myocardial wall thickening and global ejection fraction in patients with low angiographic left ventricular ejection fraction assessed by visual and quantitative resting ECG-gated 99mTc-tetrofosmin single-photon emission tomography and magnetic resonance imaging
Regional myocardial wall thickening and global ejection fraction in patients with low angiographic left ventricular ejection fraction assessed by visual and quantitative resting ECG-gated 99mTc-tetrofosmin single-photon emission tomography and magnetic resonance imaging
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通过视觉和定量静息心电图门控 99mTc-替曲膦单光子发射断层扫描和磁共振成像评估低血管造影左心室射血分数患者的局部心肌壁增厚和整体射血分数
DOI：
10.1007/s002590050253
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Schwaiger
中科院分区：
文献类型：
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作者：
J. Stollfuss;F. Haas;I. Matsunari;J. Neverve;S. Nekolla;J. Schneider;Ullrich Schricke;S. Ziegler;M. Schwaiger
抽象的。我们研究了在血管造影LVEF较低的患者中，使用可视化和定量锝99 m替曲膦ECG门控单光子发射断层扫描（SPET）评估局部心肌壁增厚（WT）和左心室（LV）射血分数（EF），并与门控磁共振成像（MRI）进行比较。门控SPET使用99 mTc标记的流动示踪剂提供了潜在的心肌灌注和LV功能的同时评估。关于在低LVEF患者中使用视觉和定量门控SPET的数据很少。在这项研究中，研究了21例血管造影LVEF较低（平均37%±5%）的患者。在48 h内进行静息门控99 mTc-tetrofosmin SPET和门控MRI。通过目视判读（5分）和基于计数增加的定量分析评估WT。MRI测量的EF值与门控SPET测量的EF值具有良好的一致性（平均EF值：33%±12% vs 35%± 11%，r = 0.86，P<0.001）。对于目视SPET WT分析，MRI WT评分点之间差异的受试者操作者特征曲线下面积（AUC）范围为0.60 - 0.66，δ计数增加值为0.59 - 0.71，% WT为0.46 - 0.60，表明WT类别之间存在实质性重叠。MRI与门控SPET之间视觉WT的绝对一致性范围为25%至57%（kappa 0.03-0.25），取决于示踪剂摄取，并且局限于中度至重度灌注缺损区域（kappa 0.03-0.13）。结论：门控SPET可可靠估计血管造影LVEF较低患者的局部WT和整体功能。
Abstract. We investigated the use of visual and quantitative technetium 99m tetrofosmin ECG-gated single-photon emission tomography (SPET) for the assessment of regional myocardial wall thickening (WT) and left ventricular (LV) ejection fraction (EF) in comparison with gated magnetic resonance imaging (MRI) in patients with a low angiographic LVEF. Gated SPET using 99mTc-labelled flow tracers offers potential for simultaneous assessment of myocardial perfusion and LV function. Few data are available on the use of visual and quantitative gated SPET in patients with low LVEF. In this study 21 patients with low angiographic LVEF (mean 37%±5%) were studied. Resting gated 99mTc-tetrofosmin SPET and gated MRI were performed within 48 h. WT was assessed by visual interpretation (five point score) and quantitative analysis based on count increase. There was good agreement for EF measurements by MRI and gated SPET (mean EF: 33%±12% vs 35%±11%, r = 0.86, P<0.001). Areas under receiver operator characteristic curves (AUC) for differentiation between MRI WT score points ranged from 0.60 to 0.66 for visual SPET WT analysis, from 0.59 to 0.71 for delta count increase values and from 0.46 to 0.60 for % WT, indicating substantial overlap between WT categories. Absolute agreement for visual WT between MRI and gated SPET ranged from 25% to 57% (kappa 0.03–0.25) depending on tracer uptake, and was limited in areas with moderate to severe perfusion defects (kappa 0.03–0.13). It is concluded that gated SPET provided reliable estimates of regional WT and global function in patients with low angiographic LVEF.
DOI：
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发表时间：
1995-11
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
G. Germano;H. Kiat;P. Kavanagh;M. Moriel;M. Mazzanti;H. Su;K. V. Train;D. Berman
通讯作者：
G. Germano;H. Kiat;P. Kavanagh;M. Moriel;M. Mazzanti;H. Su;K. V. Train;D. Berman
使用快速傅立叶变换近似确定计算收缩期壁增厚的准确性：基于犬和患者数据的模拟研究。
DOI：
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发表时间：
1994
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Cooke,CD;Garcia,EV;Cullom,SJ;Faber,TL;Pettigrew,RI
通讯作者：
Pettigrew,RI