The impact of drinking water, indoor dust and paint on blood lead levels of children aged 1-5 years in Montréal (Québec, Canada).
The impact of drinking water, indoor dust and paint on blood lead levels of children aged 1-5 years in Montréal (Québec, Canada).
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DOI：
10.1038/jes.2012.129
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发表时间：
2014-03
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
铅在极低剂量下就具有神经毒性，因此需要更好地描述家庭来源的铅对幼儿生物接触的影响。一项横断面调查评估了饮用水、房屋灰尘和油漆对生活在蒙特利尔（加拿大）老城区的幼儿血铅水平的影响。306名1至5岁的儿童，目前饮用自来水参与了这项研究。对于每个参与者，住宅铅测量厨房自来水，地板灰尘，窗台灰尘和房屋油漆和静脉血液样本进行了分析。采用多因素Logistic回归分析，以95%可信区间（CI）为比值比（OR），评价儿童血铅水平升高（≥ 75 th百分位数）与室内铅污染之间的关系。当平均水浓度>3.3 μg/L时，BLL ≥第75百分位数（1.78 μg/dL）与水铅相关：校正OR=4.7（95%CI：2.1-10.2）。窗台粉尘负荷>14.1 μg/ft 2也与BLL ≥1.78 μg/dL相关：校正OR=3.2（95% CI：1.3-7.8）。尽管BLL值相对较低，但自来水和室内灰尘中的铅会导致接触铅的幼儿BLL值增加。
Lead is neurotoxic at very low dose and there is a need to better characterize the impact of domestic sources of lead on the biological exposure of young children. A cross-sectional survey evaluated the contribution of drinking water, house dust and paint to blood lead levels (BLLs) of young children living in old boroughs of Montréal (Canada). Three hundred and six children aged 1 to 5 years and currently drinking tap water participated in the study. For each participant, residential lead was measured in kitchen tap water, floor dust, windowsill dust and house paint and a venous blood sample was analyzed. Multivariate logistic regression was used to evaluate the association between elevated BLL in the children (≥ 75th percentile) and indoor lead contamination by means of odds ratios (OR) using 95% confidence intervals (CI). There was an association between BLL ≥75th percentile (1.78 μg/dL) and water lead when the mean water concentration was >3.3 μg/L: adjusted OR=4.7 (95% CI: 2.1–10.2). Windowsill dust loading >14.1 μg/ft2 was also associated with BLL ≥1.78 μg/dL: adjusted OR=3.2 (95% CI: 1.3–7.8). Despite relatively low BLLs, tap water and house dust lead contribute to an increase of BLLs in exposed young children.
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影响因子：
3.3
作者：
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通讯作者：
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