Human embryonic stem cell differentiation toward regional specific neural precursors.

Human embryonic stem cell differentiation toward regional specific neural precursors.
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DOI:
10.1634/stemcells.2008-0543
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发表时间:
2009-01
期刊:
Stem cells (Dayton, Ohio)
影响因子:
--
通讯作者:
Stojković M
Stojković M
中科院分区:
其他
文献类型:
--
作者:
Erceg S;Ronaghi M;Stojković M

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人类胚胎干细胞(HESCs)是一种自我更新的多能细胞,具有分化为多种细胞类型的能力。这一潜力代表着一个有希望的来源,通过提供无限的所有细胞类型,包括具有神经特征的细胞,来克服许多人类疾病。因此,本文综述了人胚胎干细胞在体外条件下的早期神经发育和分化潜能,同时探讨了分化后的人胚胎干细胞在神经组织和细胞再生治疗中的潜在应用。
Human embryonic stem cells (hESCs) are self-renewing pluripotent cells that have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types, including cells with neural characteristics. Therefore, this review summarizes early neural development and the potential of hESCs to differentiate under in vitro conditions, examining at the same time the potential use of differentiated hESCs for therapeutic applications for neural tissue and cell regeneration.
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