Metabolites, genome organization, and cellular differentiation gene programs.
Metabolites, genome organization, and cellular differentiation gene programs.
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DOI：
10.1016/j.coi.2018.01.005
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发表时间：
2018-04
影响因子：
7
通讯作者：
Weinmann AS
中科院分区：
文献类型：
--
作者：
Chisolm DA;Weinmann AS
营养环境和代谢在细胞分化中起着动态作用，研究正在阐明有助于这一过程的机制。代谢酶是一个有效的桥梁，有助于将营养状态的信息转化为基因组的特定解释。这种活动的一部分涉及代谢物在调节表观遗传过程中的作用，以及代谢物在调节基因组组织中的新认识的作用。在这篇综述中，我们将重点介绍最近的研究，已确定的作用，代谢的组织和基因组的解释，以及这如何影响细胞分化的决定。我们将整合有关营养素（如谷氨酰胺）如何调节代谢物（如α-酮戊二酸）的信息，并强调这些途径如何影响表观遗传状态以及CTCF关联和基因组组织。我们还将讨论与胚胎干细胞（ES）和T细胞相关的正常分化状态之间的机制相似性和差异，以及这可能与失调状态（如与肿瘤浸润淋巴细胞相关的状态）有关。
The nutrient environment and metabolism play a dynamic role in cellular differentiation and research is elucidating the mechanisms that contribute to this process. Metabolites serve as an effective bridge that helps to translate information about nutrient states into specific interpretations of the genome. Part of this activity relates to the role for metabolites in regulating epigenetic processes as well as a newly appreciated role for metabolites in the regulation of genome organization. In this review, we will highlight recent research that has defined roles for metabolism in the organization and interpretation of the genome and how this influences cellular differentiation decisions. We will integrate information about how nutrients, such as glutamine, regulate metabolites, such as alpha-ketoglutarate, and highlight how these pathways influence epigenetic states as well as CTCF association and genome organization. We will also discuss mechanistic similarities and differences between normal differentiation states associated with embryonic stem (ES) cells and T cells and how this might relate to dysregulated states such as those associated with tumor infiltrating lymphocytes.
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影响因子：
64.5
作者：
Kaelin WG Jr;McKnight SL
通讯作者：
McKnight SL
DOI：
10.1126/science.1226603
发表时间：
2013-01-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Shyh-Chang N;Locasale JW;Lyssiotis CA;Zheng Y;Teo RY;Ratanasirintrawoot S;Zhang J;Onder T;Unternaehrer JJ;Zhu H;Asara JM;Daley GQ;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.5
作者：
Gomez-Velazquez M;Badia-Careaga C;Lechuga-Vieco AV;Nieto-Arellano R;Tena JJ;Rollan I;Alvarez A;Torroja C;Caceres EF;Roy AR;Galjart N;Delgado-Olguin P;Sanchez-Cabo F;Enriquez JA;Gomez-Skarmeta JL;Manzanares M
通讯作者：
Manzanares M
DOI：
10.1038/nrg3663
发表时间：
2014-04
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Ong CT;Corces VG
通讯作者：
Corces VG
影响因子：
64.5
作者：
Ho PC;Bihuniak JD;Macintyre AN;Staron M;Liu X;Amezquita R;Tsui YC;Cui G;Micevic G;Perales JC;Kleinstein SH;Abel ED;Insogna KL;Feske S;Locasale JW;Bosenberg MW;Rathmell JC;Kaech SM
通讯作者：
Kaech SM