Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome
Weight loss and weight maintenance, ambulatory blood pressure and cardiac autonomic tone in obese persons with the metabolic syndrome
复制标题
肥胖代谢综合征患者的体重减轻和体重维持、动态血压和心脏自主神经张力
DOI：
10.1097/00004872-200302000-00029
复制
发表时间：
2003
影响因子：
4.9
通讯作者：
L. Niskanen
中科院分区：
文献类型：
--
作者：
D. Laaksonen;T. Laitinen;Jonas Schönberg;A. Rissanen;L. Niskanen
心脏自主神经功能可能在肥胖相关性高血压中发挥作用。大多数关于体重减轻对血压和自主神经功能影响的研究没有区分急性或持续体重减轻和体重减轻后的稳态体重维持。目的：我们试图澄清动态血压，心率和心率变异性的变化，通过频谱分析评估快速减肥和延长体重维持。研究对象腹型肥胖（体重指数35.2 ± 2.1 kg/m2，腰围114.3 ± 9.0 cm）男性和女性（n = 41）代谢综合征患者。方法和结果完成1年体重维持期的34名男性和女性在9周极低热量饮食期间减掉了14.6 ± 3.5公斤，并在试验结束时保持了12.5 ± 7.5公斤的体重减轻。在饮食期间，24小时动态血压显著下降（−9.0 ± 8.0/−4.6 ± 4.9 mmHg），但在体重维持结束时已升至接近基线水平（−2.2 ± 8.2 /−1.2 ± 6.1 mmHg）。在快速减肥期间，夜间心率下降（−5.5 ± 9.6次/分钟，P = 0.012），在5分钟受控呼吸期间测量的心率变异性总功率和低频功率增加了46-56%（P = 0.003-0.09）。这些变化在体重维持期间逐渐减弱，只有夜间心率的变化在体重维持1年后仍具有边缘意义（-3.6 ± 8.6次/分，P = 0.063）。心率变异性高频功率在体重减轻和体重维持期间趋于增加。结论尽管成功维持体重，但快速减肥后动态血压的下降在很大程度上是短暂的。副交感神经张力的增加更持久，但在1年的体重维持期间也逐渐减弱。
Background Cardiac autonomic function may play a role in obesity-associated hypertension. Most studies on the effects of weight loss on blood pressure and autonomic function do not distinguish between acute or continuing weight loss and steady-state weight maintenance after weight loss. Objectives We sought to clarify the changes in ambulatory blood pressure, heart rate and heart rate variability as assessed by spectral analysis during rapid weight loss and extended weight maintenance. Participants Abdominally obese (body mass index 35.2 ± 2.1 kg/m2, waist 114.3 ± 9.0 cm) men and women (n = 41) with the metabolic syndrome. Methods and results The 34 men and women completing the 1-year weight maintenance period lost 14.6 ± 3.5 kg during the 9-week very-low-calorie diet and maintained a 12.5 ± 7.5 kg weight loss to the end of the trial. Ambulatory 24-h blood pressure decreased dramatically during the diet (−9.0 ± 8.0/−4.6 ± 4.9 mmHg), but had risen to near baseline levels by the end of weight maintenance (−2.2 ± 8.2 /−1.2 ± 6.1 mmHg). Night-time heart rate decreased (−5.5 ± 9.6 beats/min, P = 0.012), and heart rate variability total and low-frequency power measured during 5 min of controlled breathing increased by 46–56% (P = 0.003–0.09) during rapid weight loss. These changes gradually attenuated during weight maintenance, and only the change in night-time heart rate was still of borderline significance after 1 year of weight maintenance (−3.6 ± 8.6 beats/min, P = 0.063). Heart rate variability high-frequency power tended to increase during weight loss and weight maintenance. Conclusion Despite successful weight maintenance, the decrease in ambulatory blood pressure after rapid weight loss was largely transient. The increase in parasympathetic tone was more sustained, but also gradually attenuated during 1 year of weight maintenance.
DOI：
10.1093/ajcn/71.6.1421
发表时间：
2000-06
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
M. Rosenbaum;J. Hirsch;E. Murphy;R. Leibel
通讯作者：
M. Rosenbaum;J. Hirsch;E. Murphy;R. Leibel
通过中心静脉压和呼吸调节血压。
影响因子：
37.8
作者：
Triedman,JK;Saul,JP
通讯作者：
Saul,JP
影响因子：
--
作者：
Blumenthal, JA;Sherwood, A;Hinderliter, A
通讯作者：
Hinderliter, A