Modeling the contributions of Ca2+ flows to spontaneous Ca2+ oscillations and cortical spreading depression-triggered Ca2+ waves in astrocyte networks.
Modeling the contributions of Ca2+ flows to spontaneous Ca2+ oscillations and cortical spreading depression-triggered Ca2+ waves in astrocyte networks.
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DOI：
10.1371/journal.pone.0048534
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Li P
中科院分区：
文献类型：
--
作者：
Li B;Chen S;Zeng S;Luo Q;Li P
星形胶质细胞通过Ca 2+信号参与脑功能，包括Ca 2+波和Ca 2+振荡。目前，星形胶质细胞内钙信号的作用机制尚不完全清楚。在这里，我们提出了一个计算模型，以指定不同的Ca 2+流量之间的细胞外空间，细胞质和内质网的星形胶质细胞自发的Ca 2+振荡（卡斯）和皮层扩散抑制（CSD）触发的Ca 2+波（CSDCWs）在一维星形胶质细胞网络的产生的相对贡献。该模型表明，卡斯主要依赖于从星形胶质细胞的内部存储释放的Ca 2+，和CSDCW主要依赖于电压门控Ca 2+内流。这表明，电压门控性Ca ~（2+）内流在CSD过程中，即使在耗尽内部Ca ~（2+）储存后，也能够产生Ca ~（2+）波。此外，该模型研究了卡斯和CSDCW之间的相互作用，并表明，通过CSDCW抑制卡斯，而卡斯不阻止CSDCW的产生。这项工作定量分析了星形胶质细胞Ca 2+信号的产生，并表明CSDCW和非CSDCW的不同机制。研究不同类型的Ca 2+信号可能有助于理解星形胶质细胞参与脑功能信息处理的方式。
Astrocytes participate in brain functions through Ca2+ signals, including Ca2+ waves and Ca2+ oscillations. Currently the mechanisms of Ca2+ signals in astrocytes are not fully clear. Here, we present a computational model to specify the relative contributions of different Ca2+ flows between the extracellular space, the cytoplasm and the endoplasmic reticulum of astrocytes to the generation of spontaneous Ca2+ oscillations (CASs) and cortical spreading depression (CSD)-triggered Ca2+ waves (CSDCWs) in a one-dimensional astrocyte network. This model shows that CASs depend primarily on Ca2+ released from internal stores of astrocytes, and CSDCWs depend mainly on voltage-gated Ca2+ influx. It predicts that voltage-gated Ca2+ influx is able to generate Ca2+ waves during the process of CSD even after depleting internal Ca2+ stores. Furthermore, the model investigates the interactions between CASs and CSDCWs and shows that the pass of CSDCWs suppresses CASs, whereas CASs do not prevent the generation of CSDCWs. This work quantitatively analyzes the generation of astrocytic Ca2+ signals and indicates different mechanisms underlying CSDCWs and non-CSDCWs. Research on the different types of Ca2+ signals might help to understand the ways by which astrocytes participate in information processing in brain functions.
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DOI：
10.1073/pnas.89.20.9895
发表时间：
1992-10-15
影响因子：
11.1
作者：
DEYOUNG, GW;KEIZER, J
通讯作者：
KEIZER, J
影响因子：
1.6
作者：
Despa, SI
通讯作者：
Despa, SI
影响因子：
2
作者：
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通讯作者：
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影响因子：
6.2
作者：
D'ascenzo, M;Vairano, M;Grassi, C
通讯作者：
Grassi, C
影响因子：
2
作者：
Edwards, James R.;Gibson, William G.
通讯作者：
Gibson, William G.