β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase.
β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase.
复制标题
年轻男性和女性的β-肾上腺素能介导的血管舒张：环氧合酶抑制一氧化氮合酶。
DOI：
10.1152/ajpheart.00886.2015
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Schrage,WilliamG
中科院分区：
文献类型：
--
作者：
Limberg,JacquelineK;Johansson,RebeccaE;Peltonen,GarrettL;Harrell,JohnW;Kellawan,JMikhail;Eldridge,MarloweW;Sebranek,JoshuaJ;Schrage,WilliamG
We tested the hypothesis that women exhibit greater vasodilator responses to β-adrenoceptor stimulation compared with men. We further hypothesized women exhibit a greater contribution of nitric oxide synthase and cyclooxygenase to β-adrenergic-mediated vasodilation compared with men. Forearm blood flow (Doppler ultrasound) was measured in young men (n= 29, 26 ± 1 yr) and women (n= 33, 25 ± 1 yr) during intra-arterial infusion of isoproterenol (β-adrenergic agonist). In subset of subjects, isoproterenol responses were examined before and after local inhibition of nitric oxide synthase [NG-monomethyl-l-arginine (l-NMMA); 6 male/10 female] and/or cyclooxygenase (ketorolac; 5 male/5 female). Vascular conductance (blood flow ÷ mean arterial pressure) was calculated to assess vasodilation. Vascular conductance increased with isoproterenol infusion (P< 0.01), and this effect was not different between men and women (P= 0.41).l-NMMA infusion had no effect on isoproterenol-mediated dilation in men (P> 0.99) or women (P= 0.21). In contrast, ketorolac infusion markedly increased isoproterenol-mediated responses in both men (P< 0.01) and women (P= 0.04) and this rise was lost with subsequentl-NMMA infusion (men,P< 0.01; women,P< 0.05). β-Adrenergic vasodilation is not different between men and women and sex differences in the independent contribution of nitric oxide synthase and cyclooxygenase to β-mediated vasodilation are not present. However, these data are the first to demonstrate β-adrenoceptor activation of cyclooxygenase suppresses nitric oxide synthase signaling in human forearm microcirculation and may have important implications for neurovascular control in both health and disease.
登录
查看更多内容
兔冠状动脉内皮细胞中 β 肾上腺素能受体刺激的前列环素合成是通过选择性激活磷脂酶 D 介导的：腺苷 35-环单磷酸的抑制。
影响因子：
3.5
作者：
Y. Ruan;H. Kan;K. Malik
通讯作者：
K. Malik
影响因子：
8.3
作者：
Cardillo, C;Kilcoyne, CM;Panza, JA
通讯作者：
Panza, JA
DOI：
10.1161/01.cir.0000093194.21109.ec
发表时间：
2003-11
期刊：
Circulation: Journal of the American Heart Association
影响因子：
--
作者：
Takehiro Yamada;T. Fujino;Koh-ichi Yuhki;A. Hara;H. Karibe;O. Takahata;Y. Okada;C. Xiao;K. Takayama;Shuhko Kuriyama;T. Taniguchi;T. Shiokoshi;Y. Ohsaki;K. Kikuchi;S. Narumiya;F. Ushikubi
通讯作者：
Takehiro Yamada;T. Fujino;Koh-ichi Yuhki;A. Hara;H. Karibe;O. Takahata;Y. Okada;C. Xiao;K. Takayama;Shuhko Kuriyama;T. Taniguchi;T. Shiokoshi;Y. Ohsaki;K. Kikuchi;S. Narumiya;F. Ushikubi
吲哚美辛对交感神经刺激或外源性去甲肾上腺素引起的绵羊离体冠状动脉松弛的增强作用。
DOI：
10.1016/s0031-6989(84)80102-2
发表时间：
1984
期刊：
Pharmacological research communications
影响因子：
--
作者：
R. Miller;E. Cornish;R. Goldie
通讯作者：
R. Goldie
一氧化氮和前列腺素在人类骨骼肌中的贡献的激动剂依赖性变异性。
DOI：
10.1152/japplphysiol.00966.2004
发表时间：
2005
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Schrage,WilliamG;Dietz,NikiM;Eisenach,JohnH;Joyner,MichaelJ
通讯作者：
Joyner,MichaelJ