3H‐estradiol and 3H‐R5020 binding in cytosols of normal and neoplastic human ovarian tissue
3H‐estradiol and 3H‐R5020 binding in cytosols of normal and neoplastic human ovarian tissue
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3H-雌二醇和 3H-R5020 在正常和肿瘤性人卵巢组织细胞质中的结合
DOI：
10.1002/ijc.2910310512
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发表时间：
1983
影响因子：
6.4
通讯作者：
H. Grill
中科院分区：
文献类型：
--
作者：
K. Pollow;A. Schmidt;G. Hoffmann;G. Schweikhart;R. Kreienberg;B. Manz;H. Grill
研究了正常和异常卵巢组织中的高亲和力细胞质雌激素和孕激素受体。在65%的恶性肿瘤中可检测到雌二醇受体，在36%的恶性肿瘤中可检测到孕酮受体;所有恶性卵巢组织中有39%的雌二醇和孕酮受体阳性。当受体结合>5 fM类固醇/mg胞质溶胶蛋白时，肿瘤被认为是受体阳性的。受体状态与组织病理学诊断之间无相关性。在月经周期不同阶段收集的正常卵巢组织中，未检测到[<3>H]-雌二醇和[<3>H]-R5020结合的变化。两种类固醇激素的受体浓度与绝经状态的分析表明，绝经后妇女的水平最高。当两组与胞浆雌激素受体状态相关的晚期卵巢癌患者在两种不同的治疗方案（胞浆化疗加和不加他莫昔芬）方面进行比较时，没有发现显著差异。
High‐affinity cytoplasmic estrogen and progesterone receptors in normal and abnormal ovarian tissues were studied. Estradiol receptor was detectable in 65% and progesterone receptor in 36% of the malignant tumors; 39% of all malignant ovarian tissues were estradiol‐ as well as progesterone‐receptor‐positive. Tumors were said to be receptor‐positive when the receptors bound >5 fM steroid/mg cytosol protein. No correlations were found between receptor status and histopathological diagnosis. In normal ovarian tissues collected at various phases of the menstrual cycle no changes in [<3>H]‐estradiol and [<3>H]‐R5020 binding could be detected. Analysis of the receptor concentration for both steroid hormones with regard to the menopausal status demonstrated highest levels in postmenopausal women. No significant difference could be found when two groups of patients with advanced ovarian carcinoma associated with the cytosol estrogen receptor status were compared in terms of two different therapeutic schemes (cytosolic chemotherapy with and without tamoxifen).
影响因子：
7.2
作者：
P. E. Schwartz;V. Livolsi;N. Hildreth;N. MacLusky;Naftolin Fn;A. Eisenfeld
通讯作者：
P. E. Schwartz;V. Livolsi;N. Hildreth;N. MacLusky;Naftolin Fn;A. Eisenfeld