Alpha smooth muscle actin expression in developing and adult human lung.
Alpha smooth muscle actin expression in developing and adult human lung.
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阿尔法平滑肌肌动蛋白在发育中和成人肺中的表达。
DOI：
10.1111/j.1432-0436.1990.tb00547.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Robert B. Low
中科院分区：
文献类型：
--
作者：
Kevin O. Leslie;John J. Mitchell;J. Woodcock;Robert B. Low
含有平滑肌肌动蛋白的肌成纤维细胞样细胞在肺损伤和修复中已被发现。这些细胞在结构结构、位置和缺乏平滑肌肌球蛋白方面不同于典型的平滑肌细胞。它们的祖先是未知的。我们假设这些细胞可能具有对肺形态发生至关重要的发育类似物。利用一种针对α平滑肌肌动蛋白（ASMA）的高特异性单克隆抗体对发育和成人肺组织进行了研究。对ASMA有免疫反应的细胞（ASMA细胞）在出生前以平滑肌的形式被鉴定出来，这些平滑肌投资于正在发育的脉管系统和气道结构。ASMA在未分化的间充质细胞中未在任何产前阶段表达。在发育后期，肺腺泡内的ASMA细胞随着终末气道和血管的复杂性成比例地增加。在出生后早期，膨大肺内ASMA细胞的具体分布变得更加清晰，确定了3个群体：(1)典型的平滑肌覆盖大气道和血管；(2)腺泡内的小细胞簇分布在间隔尖端，向肺泡管内突出；(3)肺泡囊内的单个细胞稀疏分布在单个肺泡连接处附近，常伴有小血管。我们的结论是，ASMA细胞只出现在发育中的大、小气道和肺血管中，它们可能在发育过程中的分支形态发生中起关键作用。
Myofibroblast-like cells containing smooth muscle actin have been identified in lung injury and repair. These cells differ from typical smooth muscle cells by architectural configuration, location and lack of smooth muscle myosin. Their progenitors are unknown. We hypothesized that these cells might have a developmental analog critical to lung morphogenesis. Lung tissue from developing and adult human lungs was studied using a highly specific monoclonal antibody directed against alpha smooth muscle actin (ASMA). Cells immunoreactive for ASMA (ASMA cells) were identified prenatally in the form of smooth muscle investing the developing vasculature and airway structures. ASMA was not expressed in undifferentiated mesenchymal cells at any prenatal stage. Late in development, ASMA cells within the lung acinus increased proportionally to terminal airway and vascular complexity. In the early postnatal period, the specific distribution of ASMA cells within inflated lung became clearer, and three populations were identified: (1) typical smooth muscle investing the large airways and blood vessels; (2) small clusters of cells within the acinus distributed at the tips of septa protruding into the alveolar duct; (3) individual cells within the alveolar sac sparsely distributed near the junctions of individual alveoli, frequently in association with small blood vessels. We conclude that ASMA cells appear only in developing small and large airways and pulmonary vessels and that they may play a critical role in branching morphogenesis during development.
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慢性高氧性肺损伤的修复：肺超微结构和基质的变化。
影响因子：
3.6
作者：
Durr,RA;Dubaybo,BA;Thet,LA
通讯作者：
Thet,LA
博来霉素诱导的肺纤维化动物模型中离体肺实质的收缩性增加。
DOI：
10.1164/arrd.1982.125.1.89
发表时间：
1982
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Evans,JN;Kelley,J;Low,RB;Adler,KB
通讯作者：
Adler,KB
人肺纤维化中含有肌动蛋白的细胞。
DOI：
--
发表时间：
1981
期刊：
The American journal of pathology
影响因子：
--
作者：
Adler,KB;Craighead,JE;Vallyathan,NV;Evans,JN
通讯作者：
Evans,JN
大鼠肺外周肌动蛋白：细胞松弛素诱导的 S1 标记和结构变化。
DOI：
10.1177/31.11.6684669
发表时间：
1983
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Tsilibary,EC;Williams,MC
通讯作者：
Williams,MC
博来霉素损伤的大鼠肺实质细胞中的α-平滑肌肌动蛋白。
DOI：
--
发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Mitchell,J;Woodcock-Mitchell,J;Reynolds,S;Low,R;Leslie,K;Adler,K;Gabbiani,G;Skalli,O
通讯作者：
Skalli,O