Vitamin D deficiency promotes prostatic hyperplasia in middle-age mice through exacerbating local inflammation
Vitamin D deficiency promotes prostatic hyperplasia in middle-age mice through exacerbating local inflammation
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维生素D缺乏通过加剧局部炎症促进中年小鼠前列腺增生
DOI：
10.1016/j.jsbmb.2018.04.006
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发表时间：
2018-09
影响因子：
4.1
通讯作者：
De-Xiang Xu
中科院分区：
文献类型：
--
作者：
Zhi-Hui Zhang;Biao Luo;Shen Xu;Lin Fu;Yuan-Hua Chen;Cheng Zhang;Hua Wang;Dong-Dong Xie;De-Xiang Xu
维生素D缺乏症在孕妇和儿童中尤为普遍。我们最近的研究表明，早期维生素D缺乏会干扰睾丸发育。本研究探讨了生命早期维生素D缺乏对中年小鼠前列腺增生的影响。对照组母鼠及其雄性仔鼠饲喂标准饲料。VDD组母鼠在整个妊娠期和哺乳期均饲喂维生素D缺乏（VDD）饲料。断奶后，雄性幼仔继续用VDD饲料喂养。正如预期，在喂食VDD的小鼠中观察到前列腺重量升高和前列腺增生。前列腺Ki-67阳性上皮细胞（增殖标志物）的数量在喂食VDD的小鼠中增加。进一步分析发现，维生素D缺乏促进了中年小鼠前列腺的炎症浸润和间质纤维化。此外，维生素D缺乏还激活了中年小鼠前列腺中NF-κB，上调了IL-6 mRNA的表达。此外，维生素D缺乏激活了前列腺STAT 3，这是中年小鼠的一种增殖途径。有趣的是，VDD诱导的前列腺炎症和增生被部分逆转时，VDD饮食取代标准饮食。这些结果提供了证据，证明早期维生素D缺乏通过加剧局部炎症促进中年小鼠的前列腺增生。
Vitamin D deficiency is especially prevalent in pregnant women and children. Our recent study demonstrated that vitamin D deficiency in early life disturbed testicular development. This study investigated the effects of vitamin D deficiency in early life on prostatic hyperplasia in middle-aged mice. In control group, dams and their male pups were fed with standard-chow diets. In VDD group, dams were fed with vitamin D deficient (VDD) diets throughout pregnancy and lactation. After weaning, male pups continued to be fed with VDD diets. As expected, prostate weight was elevated and prostatic hyperplasia was observed in VDD-fed mice. The number of prostatic Ki-67-positive epithelial cells, a proliferation marker, was increased in VDD-fed mice. Further analysis found that vitamin D deficiency promoted inflammatory infiltration and stromal fibrosis in prostate of middle-aged mice. Moreover, vitamin D deficiency activated NF-κB and up-regulatedIl-6mRNA in prostate of middle-aged mice. In addition, vitamin D deficiency activated prostatic STAT3, a proliferation pathway in middle-aged mice. Of interest, VDD-induced prostatic inflammation and hyperplasia were partially reversed when VDD diets was replaced with standard diets. These results provide evidence that vitamin D deficiency in early life promotes prostatic hyperplasia in middle-aged mice through exacerbating local inflammation.
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DOI：
10.1074/jbc.m112.355164
发表时间：
2012-04
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
Xiaohai Wang;Wen-Jye Lin;K. Izumi;Qi Jiang;K. Lai;Defeng Xu;Lei-Ya Fang;T. Lu;Lei Li;Shujie Xia;Chawnshang Chang
通讯作者：
Xiaohai Wang;Wen-Jye Lin;K. Izumi;Qi Jiang;K. Lai;Defeng Xu;Lei-Ya Fang;T. Lu;Lei Li;Shujie Xia;Chawnshang Chang
影响因子：
5.9
作者：
Choi R;Kim S;Yoo H;Cho YY;Kim SW;Chung JH;Oh SY;Lee SY
通讯作者：
Lee SY
影响因子：
5
作者：
Schenk, Jeannette M.;Kristal, Alan R.;Thompson, Ian M.
通讯作者：
Thompson, Ian M.
影响因子：
11.2
作者：
Kroon, Paula;Berry, Paul A.;Collins, Anne T.
通讯作者：
Collins, Anne T.
影响因子：
7.1
作者：
Andersen, Louise B.;Jorgensen, Jan S.;Christesen, Henrik T.
通讯作者：
Christesen, Henrik T.