High prevalence of vitamin D deficiency in pregnant Korean women: the first trimester and the winter season as risk factors for vitamin D deficiency.
High prevalence of vitamin D deficiency in pregnant Korean women: the first trimester and the winter season as risk factors for vitamin D deficiency.
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DOI：
10.3390/nu7053427
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发表时间：
2015-05-11
期刊：
影响因子：
5.9
通讯作者：
Lee SY
中科院分区：
文献类型：
--
作者：
Choi R;Kim S;Yoo H;Cho YY;Kim SW;Chung JH;Oh SY;Lee SY
我们调查了韩国妇女在怀孕期间的维生素D状况，并评估了维生素D缺乏对两种妊娠结局的影响;早产和小于胎龄儿的出生。我们测量了220名前瞻性招募的韩国孕妇的血清25-羟基维生素D水平，并将这些水平与500名健康非孕妇的血清25-羟基维生素D水平进行了比较。我们根据患者的人口统计学资料、季节和产科特征分析了维生素D状况;此外，我们还评估了妊娠结局。孕妇和健康非孕妇中维生素D缺乏（<20 ng/mL）的总患病率分别为77.3%和79.2%;重度维生素D缺乏（<10 ng/mL）的患病率分别为28.6%和7.2%（p < 0.05）。维生素D缺乏症在冬季（100%）比在夏季（45.5%）在韩国孕妇更普遍。妊娠早期维生素D缺乏的风险高于妊娠晚期（校正OR 4.3; p < 0.05）。维生素D缺乏症与任何妊娠结局之间均无显著相关性。有必要进一步研究韩国妇女怀孕期间缺乏维生素D的长期后果。
We investigated the vitamin D status of Korean women during pregnancy and assessed the effects of vitamin D deficiency on two pregnancy outcomes; preterm births and the births of small for gestational age. We measured the serum 25-hydroxyvitamin D levels in 220 pregnant Korean women who were recruited prospectively and compared these levels with those of 500 healthy non-pregnant women. We analyzed vitamin D status according to patient demographics, season, and obstetrical characteristics; moreover, we also assessed pregnancy outcomes. The overall prevalence of vitamin D deficiency(<20 ng/mL) in pregnant women and healthy non-pregnant women was 77.3% and 79.2%; respectively; and the prevalence of severe vitamin D deficiency (<10 ng/mL) was 28.6% and 7.2%; respectively (p < 0.05). Vitamin D deficiency was more prevalent in the winter (100%) than in the summer (45.5%) in pregnant Korean women. A higher risk of vitamin D deficiency was observed in the first trimester than in the third trimester (adjusted OR 4.3; p < 0.05). No significant association was observed between vitamin D deficiency and any of the pregnancy outcomes examined. Further research focusing on the long-term consequences of vitamin D deficiency during pregnancy in Korean women is warranted.
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