Improved early postresuscitation EEG activity for animals treated with hypothermia predicted 96 hr neurological outcome and survival in a rat model of cardiac arrest.
Improved early postresuscitation EEG activity for animals treated with hypothermia predicted 96 hr neurological outcome and survival in a rat model of cardiac arrest.
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DOI：
10.1155/2013/312137
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发表时间：
2013
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Chen B;Song FQ;Sun LL;Lei LY;Gan WN;Chen MH;Li Y
目的.通过定量描述大鼠心脏骤停复苏后早期脑电图，研究低温对96小时神经功能预后和存活率的影响。材料与方法。在20只雄性Sprague-Dawley大鼠中，通过高频经食管心脏起搏诱导心脏骤停。心脏骤停5分钟后开始复苏。复苏后立即将动物随机分为2小时低温组（N = 10）或常温组（N = 10）。连续记录EEG、ECG、主动脉压和核心温度6小时。在复苏后96小时内，每天评估神经学结果。结果两组之间的基线测量值和复苏结果无差异。然而，低温组的96小时神经功能缺损评分（204 ± 255 vs 500 ± 0，P = 0.005）和存活率（6/10 vs 0/10，P = 0.011）明显更好。复苏后早期EEG定量分析显示，爆发频率和频谱熵在低温组有很大改善，并与96小时的神经功能预后和生存率相关。结论在爆发抑制期间改善的爆发频率和在恢复低温治疗的动物的连续背景EEG活动后保留的频谱熵预测在该心脏骤停大鼠模型中有利的神经结果和存活。
Purpose. To investigate the effect of hypothermia on 96 hr neurological outcome and survival by quantitatively characterizing early postresuscitation EEG in a rat model of cardiac arrest. Materials and Methods. In twenty male Sprague-Dawley rats, cardiac arrest was induced through high frequency transesophageal cardiac pacing. Cardiopulmonary resuscitation was initiated after 5 mins untreated arrest. Immediately after resuscitation, animals were randomized to either 2 hrs of hypothermia (N = 10) or normothermia (N = 10). EEG, ECG, aortic pressure, and core temperature were continuously recorded for 6 hrs. Neurological outcome was evaluated daily during the 96 hrs postresuscitation period. Results. No differences in the baseline measurements and resuscitation outcome were observed between groups. However, 96 hr neurological deficit score (204 ± 255 versus 500 ± 0, P = 0.005) and survival (6/10 versus 0/10, P = 0.011) were significantly better in the hypothermic group. Quantitative analysis of early postresuscitation EEG revealed that burst frequency and spectrum entropy were greatly improved in the hypothermic group and correlated with 96 hr neurological outcome and survival. Conclusion. The improved burst frequency during burst suppression period and preserved spectrum entropy after restoration of continuous background EEG activity for animals treated with hypothermia predicted favorable neurological outcome and survival in this rat model of cardiac arrest.
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影响因子：
4.4
作者：
Deboer, T
通讯作者：
Deboer, T
影响因子：
6.5
作者：
Oh, Sang Hoon;Park, Kyu Nam;Shon, Young Min
通讯作者：
Shon, Young Min
DOI：
10.1164/ajrccm.164.7.2007083
发表时间：
2001-10-01
影响因子：
24.7
作者：
Kamohara, T;Weil, MH;Bisera, J
通讯作者：
Bisera, J
影响因子：
38.9
作者：
Meynaar, IA;Oudemans-van Straaten, HM;Zandstra, DF
通讯作者：
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影响因子：
8.8
作者：
EDGREN, E;HEDSTRAND, U;RONQUIST, G
通讯作者：
RONQUIST, G