Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data.
Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data.
复制标题
DOI：
10.1007/s11912-023-01423-3
复制
发表时间：
2023-08
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
相关研究应利用临床试验框架进行生物谱分析，以深入了解干预的生物活性，并促进进一步改善患者结局的未来试验的迭代。在儿科细胞免疫治疗试验中，相关研究使人们能够更深入地了解T细胞动员、免疫激活的持久性、毒性模式和治疗反应的早期检测。本文就儿童中枢神经系统(CNS)肿瘤过继细胞治疗(ACT)的相关科学进行综述，重点介绍表达嵌合抗原受体(CAR)和T细胞受体(TCR)的T细胞治疗方法。我们强调了相关数据有效对齐的长期和最近了解的挑战，并为当前和未来对系列肿瘤、血清和脑脊液(CSF)生物标本的多组学分析方法提供了实用的考虑。我们强调在ACT临床试验中从中枢神经系统肿瘤患者中收集系列细胞因子和蛋白质组学的初步成功。
Correlative studies should leverage clinical trial frameworks to conduct biospecimen analyses that provide insight into the bioactivity of the intervention and facilitate iteration toward future trials that further improve patient outcomes. In pediatric cellular immunotherapy trials, correlative studies enable deeper understanding of T cell mobilization, durability of immune activation, patterns of toxicity, and early detection of treatment response. Here, we review the correlative science in adoptive cell therapy (ACT) for childhood central nervous system (CNS) tumors, with a focus on existing chimeric antigen receptor (CAR) and T cell receptor (TCR)-expressing T cell therapies. We highlight long-standing and more recently understood challenges for effective alignment of correlative data and offer practical considerations for current and future approaches to multi-omic analysis of serial tumor, serum, and cerebrospinal fluid (CSF) biospecimens. We highlight the preliminary success in collecting serial cytokine and proteomics from patients with CNS tumors on ACT clinical trials.
登录
查看更多内容
影响因子：
20.3
作者：
Gardner, Rebecca A.;Finney, Olivia;Jensen, Michael C.
通讯作者：
Jensen, Michael C.
DOI：
10.1158/1078-0432.ccr-18-0432
发表时间：
2019-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Majzner RG;Theruvath JL;Nellan A;Heitzeneder S;Cui Y;Mount CW;Rietberg SP;Linde MH;Xu P;Rota C;Sotillo E;Labanieh L;Lee DW;Orentas RJ;Dimitrov DS;Zhu Z;Croix BS;Delaidelli A;Sekunova A;Bonvini E;Mitra SS;Quezado MM;Majeti R;Monje M;Sorensen PHB;Maris JM;Mackall CL
通讯作者：
Mackall CL
影响因子：
15.9
作者：
通讯作者：
--
影响因子：
4.4
作者：
Kennedy, Jacob J.;Whiteaker, Jeffrey R.;Paulovich, Amanda G.
通讯作者：
Paulovich, Amanda G.
DOI：
10.1073/pnas.1706689114
发表时间：
2017-09-19
影响因子：
11.1
作者：
Antonios, Joseph P.;Soto, Horacio;Prins, Robert M.
通讯作者：
Prins, Robert M.