Multiparametric Whole-body MRI with Diffusion-weighted Imaging and ADC Mapping for the Identification of Visceral and Osseous Metastases From Solid Tumors.
Multiparametric Whole-body MRI with Diffusion-weighted Imaging and ADC Mapping for the Identification of Visceral and Osseous Metastases From Solid Tumors.
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DOI：
10.1016/j.acra.2018.02.010
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发表时间：
2018-11
影响因子：
4.8
通讯作者：
Pan L
中科院分区：
文献类型：
--
作者：
Jacobs MA;Macura KJ;Zaheer A;Antonarakis ES;Stearns V;Wolff AC;Feiweier T;Kamel IR;Wahl RL;Pan L
本研究的目的是探讨多参数全身弥散加权成像(WB-DWI)和表观弥散系数(ADC)图在3T磁共振T2加权成像中对患者转移瘤的检测和监测。54名受试者(32名健康受试者和22名患者)在3T磁共振扫描仪上进行了WB-DWI扫描。获取轴位、矢状位或冠状位脂肪抑制T2加权(T2WI)、T1加权(T1WI)和弥散加权成像(DWI)图像。总的MRI采集和设置时间约为45分钟。MRI上的转移性病变是根据T2WI特征确定的。在CT或PET/CT上确定病变数目。建立全身ADC图和T2WI图，绘制正常组织和异常组织的感兴趣区(ROI)图，进行定量分析。使用配对t检验进行统计分析，P<；0.05被认为具有统计学意义。CT或PET/CT发现91个转移性病变，未发现前列腺癌复发。与CT相比，多参数WB-MRI对发现转移灶具有极高的敏感性(96%)。与正常骨相比，转移性骨病变的ADC MAP值和ADC比值显著增加(p<；0.05)。在软组织中，转移灶的ADC MAP值和ADC比值均低于正常软组织。我们已经证明，多参数WB-MRI用于肿瘤分期以确定乳腺癌、前列腺癌、胰腺癌和结直肠癌的骨和内脏转移是可行的。WB-MRI可以量身定做，以适应患者的需要，这样就可以开发出“个性化的患者序列”，对治疗过程中的分期和反应进行综合评估。
The purpose of this study was to investigate the use of multiparametric, whole-body, diffusion-weighted imaging (WB-DWI) and Apparent Diffusion Coefficient (ADC) maps with T2-weighted MRI at 3T for the detection and monitoring of metastatic disease in patients. Fifty-four participants (32 healthy subjects and 22 patients) were scanned with WB-DWI methods using a 3T MRI scanner. Axial, sagittal, or coronal fat-suppressed T2-weighted (T2WI), T1-weighted(T1WI), and DWI images were acquired. Total MRI acquisition and set up time was approximately 45 minutes. Metastatic disease on MRI was confirmed based on T2WI characteristics. The number of lesions were established on Computed Tomography (CT) or PET/CT. Whole-body ADC maps and T2WI were constructed and region-of-interests (ROIs) were drawn in normal and abnormal-appearing tissue for quantitative analysis. Statistical analysis was performed using a paired t-tests and p<0.05 was considered statistically significant. There were 91 metastatic lesions detected from the CT or PET/CT with a missed recurrent lesion in the prostate. Multiparametric WB-MRI had excellent sensitivity (96%) for detection of metastatic lesions compared to CT. ADC map values and the ADC ratio in metastatic bone lesions were significantly increased (p<0.05) compared to normal bone. In soft tissue, ADC map values and ratios in metastatic lesions were decreased compared to normal soft tissue. We have demonstrated that multiparametric WB-MRI is feasible for oncologic staging to identify bony and visceral metastasis in breast, prostate, pancreatic, and colorectal cancers. WB-MRI can be tailored to fit the patient, such that an “individualized patient sequence” can be developed for a comprehensive evaluation for staging and response during treatment.
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影响因子：
82.9
作者：
Judenhofer, Martin S.;Wehrl, Hans F.;Pichler, Bernd J.
通讯作者：
Pichler, Bernd J.
影响因子：
4.8
作者：
Chen, XM;Moore, MO;Livingston, RB
通讯作者：
Livingston, RB
影响因子：
3.8
作者：
Jacobs, Michael A.;Ouwerkerk, Ronald;Stearns, Vered
通讯作者：
Stearns, Vered
影响因子：
5
作者：
Hergaden, G;O'Connell, M;Eustace, S
通讯作者：
Eustace, S
影响因子：
2.1
作者：
Axelsen, M. B.;Eshed, I.;Pedersen, S. J.
通讯作者：
Pedersen, S. J.