From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years.

From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years.
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DOI:
10.3389/fimmu.2015.00328
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发表时间:
2015
影响因子:
7.3
通讯作者:
Gordon S
Gordon S
中科院分区:
医学2区
文献类型:
--
作者:
Yona S;Gordon S

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125年前,伊利亚·梅契尼科夫(Ilya Metchnikoff)描述了吞噬作用的重要性。在这篇综述中,我们研究了巨噬细胞研究的早期起源和发展,在1916年他去世后,通过网状内皮系统的时期继续进行。对这些细胞的研究导致了免疫学、血液学、生物化学和病理学的大量文献。早期形态学和原位标记的组织学研究为了解这些细胞在稳态和病理过程中的多样性和功能能力奠定了基础。我们完成这个白细胞回顾与建立单核吞噬细胞系统命名半个世纪前。
It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review, we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the reticuloendothelial system. Studies on these cells resulted in a substantial literature spanning immunology, hematology, biochemistry, and pathology. Early histological studies on morphology and in situ labeling laid the foundations to appreciate the diversity and functional capacity of these cells in the steady state and during pathology. We complete this phagocyte retrospective with the establishment of the mononuclear phagocyte system nomenclature half a century ago.
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