Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK.
Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK.
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中链甘油三酯通过GPR120依赖性抑制CCK抑制长链甘油三酯诱导的GIP分泌。
DOI：
10.1016/j.isci.2021.102963
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发表时间：
2021-09-24
期刊：
影响因子：
5.8
通讯作者：
Inagaki N
中科院分区：
文献类型：
--
作者：
Murata Y;Harada N;Kishino S;Iwasaki K;Ikeguchi-Ogura E;Yamane S;Kato T;Kanemaru Y;Sankoda A;Hatoko T;Kiyobayashi S;Ogawa J;Hirasawa A;Inagaki N
长链甘油三酯（lct）的摄入强烈刺激肠内分泌K细胞分泌GIP，并诱导肥胖和胰岛素抵抗，部分原因是GIP分泌过多。在本研究中，我们发现中链甘油三酯（mct）在单次摄入LCT后抑制GIP分泌，并阐明了mct诱导的GIP分泌抑制的机制。野生型（WT）小鼠单次摄入LCT后，mct降低了CCK效应，CCK激动剂完全逆转了mct诱导的GIP分泌抑制。体外研究表明，中链脂肪酸（MCFAs）通过抑制GPR120信号传导抑制长链脂肪酸（LCFA）刺激的CCK分泌和细胞内Ca2+浓度的增加。长期服用mct可降低高lct饮食喂养的WT小鼠的肥胖和胰岛素抵抗，但对高lct饮食喂养的gip敲除小鼠没有作用。因此，mct诱导的GIP高分泌抑制降低了高lct饮食喂养条件下的肥胖和胰岛素抵抗。mct通过降低lct诱导的CCK作用抑制lct诱导的GIP分泌mct衍生的MCFAs有望对GPR120具有拮抗作用抑制GIP分泌可缓解高lct饲粮饲养条件下的肥胖生理学;内分泌学
Long-chain triglycerides (LCTs) intake strongly stimulates GIP secretion from enteroendocrine K cells and induces obesity and insulin resistance partly due to GIP hypersecretion. In this study, we found that medium-chain triglycerides (MCTs) inhibit GIP secretion after single LCT ingestion and clarified the mechanism underlying MCT-induced inhibition of GIP secretion. MCTs reduced the CCK effect after single LCT ingestion in wild-type (WT) mice, and a CCK agonist completely reversed MCT-induced inhibition of GIP secretion. In vitro studies showed that medium-chain fatty acids (MCFAs) inhibit long-chain fatty acid (LCFA)-stimulated CCK secretion and increase in intracellular Ca2+ concentrations through inhibition of GPR120 signaling. Long-term administration of MCTs reduced obesity and insulin resistance in high-LCT diet-fed WT mice, but not in high-LCT diet-fed GIP-knockout mice. Thus, MCT-induced inhibition of GIP hypersecretion reduces obesity and insulin resistance under high-LCT diet feeding condition. MCTs inhibit LCT-induced GIP secretion by reducing LCT-induced CCK action MCFAs derived from MCTs are expected to have antagonistic properties to GPR120 Inhibition of GIP secretion alleviates obesity under high-LCT diet feeding condition Biological sciences; Physiology; Endocrinology
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影响因子：
3.2
作者：
Harada N;Hamasaki A;Yamane S;Muraoka A;Joo E;Fujita K;Inagaki N
通讯作者：
Inagaki N
影响因子：
7.1
作者：
BACH, AC;BABAYAN, VK
通讯作者：
BABAYAN, VK
影响因子：
9.3
作者：
Dragano NRV;Solon C;Ramalho AF;de Moura RF;Razolli DS;Christiansen E;Azevedo C;Ulven T;Velloso LA
通讯作者：
Velloso LA
DOI：
10.1152/ajpendo.00358.2007
发表时间：
2008-01-01
影响因子：
5.1
作者：
Harada, Norio;Yamada, Yuichiro;Inagaki, Nobuya
通讯作者：
Inagaki, Nobuya
影响因子：
7.7
作者：
Edfalk S;Steneberg P;Edlund H
通讯作者：
Edlund H