Single neurons may encode simultaneous stimuli by switching between activity patterns.
Single neurons may encode simultaneous stimuli by switching between activity patterns.
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DOI：
10.1038/s41467-018-05121-8
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发表时间：
2018-07-13
影响因子：
16.6
通讯作者：
Groh JM
中科院分区：
文献类型：
--
作者：
Caruso VC;Mohl JT;Glynn C;Lee J;Willett SM;Zaman A;Ebihara AF;Estrada R;Freiwald WA;Tokdar ST;Groh JM
大脑如何保存关于多个同时发生的项目的信息还知之甚少。我们报告说，单个神经元可以代表多个刺激交叉信号跨时间。我们在听觉区域（下丘）记录单个单位，而猴子则定位1或2个同时发出的声音。在双声音试验中，我们发现一些神经元在整个试验或子试验时间尺度上观察到的每个单一声音的放电率之间波动。这些波动在成对的神经元中是相关的，可以通过声音开始之前的局部场电位的状态来预测，并且在一只猴子中，可以预测哪个声音将首先被报告。我们在一个单独的数据集中发现了确凿的证据，表明颞下皮层神经元对多种视觉刺激的反应存在波动的活动模式。因此，与多个项目中的每一个相对应的活动模式之间的交替可能是增强大脑处理能力的一般策略，潜在地将诸如可变神经放电、神经振荡和注意力/记忆能力的限制等不同现象联系起来。神经元代表同时呈现的刺激的神经机制还没有得到很好的理解。在这里，作者证明了这两种刺激通过单个神经元活动模式的波动交替编码。
How the brain preserves information about multiple simultaneous items is poorly understood. We report that single neurons can represent multiple stimuli by interleaving signals across time. We record single units in an auditory region, the inferior colliculus, while monkeys localize 1 or 2 simultaneous sounds. During dual-sound trials, we find that some neurons fluctuate between firing rates observed for each single sound, either on a whole-trial or on a sub-trial timescale. These fluctuations are correlated in pairs of neurons, can be predicted by the state of local field potentials prior to sound onset, and, in one monkey, can predict which sound will be reported first. We find corroborating evidence of fluctuating activity patterns in a separate dataset involving responses of inferotemporal cortex neurons to multiple visual stimuli. Alternation between activity patterns corresponding to each of multiple items may therefore be a general strategy to enhance the brain processing capacity, potentially linking such disparate phenomena as variable neural firing, neural oscillations, and limits in attentional/memory capacity. The neural mechanisms through which neurons represent simultaneously presented stimuli are not well understood. Here the authors demonstrate that the two stimuli are alternately encoded through fluctuations in the activity patterns of single neurons.
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DOI：
10.1126/science.1194908
发表时间：
2010-11-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Freiwald WA;Tsao DY
通讯作者：
Tsao DY
影响因子：
1.8
作者：
Holcombe, Alex O.;Chen, Wei-Ying
通讯作者：
Chen, Wei-Ying
影响因子：
5.3
作者：
Busch, Niko A.;Dubois, Julien;VanRullen, Rufin
通讯作者：
VanRullen, Rufin
影响因子：
2.9
作者：
GERSTEIN, GL;PERKEL, DH;SUBRAMANIAN, KN
通讯作者：
SUBRAMANIAN, KN
影响因子：
2.5
作者：
AITKIN, LM;PHILLIPS, SC
通讯作者：
PHILLIPS, SC