Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery.
Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery.
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DOI：
10.1083/jcb.200503077
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发表时间：
2005-11-21
期刊：
影响因子：
--
通讯作者：
Franzini-Armstrong C
中科院分区：
文献类型：
--
作者：
Di Biase V;Franzini-Armstrong C
骨骼肌和心肌之间的功能分离发生在脊椎动物和无脊椎动物之间，涉及两种类型横纹肌的不同收缩和控制蛋白的进化，以及不同的收缩激活机制。表面膜的电兴奋和收缩物质的激活之间的功能联系(称为兴奋-收缩[e-c]耦合)需要表膜上的电压传感器二氢吡啶受体(DHPR)和肌浆网中的钙释放通道兰尼定受体(RyR)之间的相互作用。骨骼肌和心肌具有这两种蛋白质的不同亚型，并呈现两种结构和功能上不同的相互作用模式。我们使用结构线索来追踪二分法从单一的、通用的e-c偶联类型到涉及骨骼肌激活的新机制的多样化系统的演变。我们的结果表明，随着骨骼肌特异的RyR和DHPR亚型的出现，显著的结构转变标志着从原脊索到颅骨的进化步骤。
The functional separation between skeletal and cardiac muscles, which occurs at the threshold between vertebrates and invertebrates, involves the evolution of separate contractile and control proteins for the two types of striated muscles, as well as separate mechanisms of contractile activation. The functional link between electrical excitation of the surface membrane and activation of the contractile material (known as excitation–contraction [e–c] coupling) requires the interaction between a voltage sensor in the surface membrane, the dihydropyridine receptor (DHPR), and a calcium release channel in the sarcoplasmic reticulum, the ryanodine receptor (RyR). Skeletal and cardiac muscles have different isoforms of the two proteins and present two structurally and functionally distinct modes of interaction. We use structural clues to trace the evolution of the dichotomy from a single, generic type of e–c coupling to a diversified system involving a novel mechanism for skeletal muscle activation. Our results show that a significant structural transition marks the protochordate to the Craniate evolutionary step, with the appearance of skeletal muscle–specific RyR and DHPR isoforms.
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影响因子：
7.8
作者：
Henkart, M;Landis, D M;Reese, T S
通讯作者：
Reese, T S
DOI：
10.1098/rspb.1994.0026
发表时间：
1994-02-22
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
7.8
作者：
Franzini-Armstrong, C
通讯作者：
Franzini-Armstrong, C
影响因子：
2.7
作者：
FRANZINIARMSTRONG, C;NUNZI, G
通讯作者：
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