Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review).
Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review).
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DOI：
10.3892/etm_00000037
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发表时间：
2010-03
影响因子：
2.7
通讯作者：
Matthews QL
中科院分区：
文献类型：
--
作者：
Gamble LJ;Borovjagin AV;Matthews QL
本文就整合素靶向治疗的研究进展作一综述，并探讨卵巢癌靶向治疗的最佳研究方向。细胞表面整合素靶向已被用作几种疾病的靶向治疗策略，并取得了一些成功。病毒治疗和整合素靶向的组合显示出作为靶向卵巢癌的方法的前景。更具体地说，用整合素导向的腺病毒靶向卵巢癌可能导致具有更少毒性和副作用的治疗。本文综述了整合素特异性靶向治疗对几种疾病的益处，并提出了一种独特的抗卵巢癌策略，包括将上述方法与病毒治疗相结合，作为一种潜在的抗卵巢癌治疗方法。
The purpose of this article was to review the current strategies of targeted therapy to integrins and define the best course of future research in ovarian cancer targeting. Cell surface integrin targeting has been used as a strategy for targeted therapy of several diseases with some success. The combination of virotherapy and integrin-targeting shows promise as a method for targeting ovarian cancer. More specifically, targeting of ovarian cancer with integrin-directed adenoviruses may lead to therapy with fewer toxicities and side effects. This article offers a review of the benefits of integrin-specific targeted therapy for several diseases and proposes a unique anti-ovarian cancer strategy involving the combination of the above with virotherapy as a potential anti-ovarian cancer treatment.
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DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.84.18.6471
发表时间：
1987-09-01
影响因子：
11.1
作者：
CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
4.1
作者：
Asaoka, K;Tada, M;Abe, H
通讯作者：
Abe, H
影响因子：
5.1
作者：
Alemany, R;Curiel, DT
通讯作者：
Curiel, DT
影响因子：
6.4
作者：
Buller, RE;Shahin, MS;Pegram, M
通讯作者：
Pegram, M