Metabolic profiling of Alzheimer's disease brains.
Metabolic profiling of Alzheimer's disease brains.
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DOI：
10.1038/srep02364
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发表时间：
2013
影响因子：
4.6
通讯作者：
Toyo'oka, Toshimasa
中科院分区：
文献类型：
--
作者：
Inoue, Koichi;Tsutsui, Haruhito;Akatsu, Hiroyasu;Hashizume, Yoshio;Matsukawa, Noriyuki;Yamamoto, Takayuki;Toyo'oka, Toshimasa
阿尔茨海默病（AD）是一种不可逆的进行性脑部疾病，可以在死后通过检查老年斑和大脑几个区域的神经原纤维缠结来确诊。可以预期，低分子量分子的浓度和/或定位的变化与阿尔茨海默病发生的病理变化有关，确定它们的身份将为阿尔茨海默病的过程提供有价值的信息。在这里，我们提出了明确的脑代谢分析使用超高效液相色谱结合电喷雾飞行时间质谱分析。获得的数据进行主成分分析，以区分AD/对照组的额叶和顶叶。通过s图、质谱、数据库和标准品鉴定精胺和亚精胺水平存在显著差异。基于对多胺代谢途径的研究，这些数据表明鸟氨酸的下游代谢物增加，可能暗示鸟氨酸脱羧酶活性与AD病理有关。
Alzheimer's disease (AD) is an irreversible, progressive brain disease and can be definitively diagnosed after death through an examination of senile plaques and neurofibrillary tangles in several brain regions. It is to be expected that changes in the concentration and/or localization of low-molecular-weight molecules are linked to the pathological changes that occur in AD, and determining their identity would provide valuable information regarding AD processes. Here, we propose definitive brain metabolic profiling using ultra-performance liquid chromatography coupled with electrospray time-of-flight mass spectrometry analysis. The acquired data were subjected to principal components analysis to differentiate the frontal and parietal lobes of the AD/Control groups. Significant differences in the levels of spermine and spermidine were identified using S-plot, mass spectra, databases and standards. Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology.
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影响因子：
4.1
作者：
Hejazi, Leila;Wong, Jason W. H.;Don, Anthony S.
通讯作者：
Don, Anthony S.
DOI：
10.1016/j.jalz.2010.06.001
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Kaddurah-Daouk R;Rozen S;Matson W;Han X;Hulette CM;Burke JR;Doraiswamy PM;Welsh-Bohmer KA
通讯作者：
Welsh-Bohmer KA
影响因子：
5.6
作者：
Haight, Thaddeus J.;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
4.1
作者：
Grimm, Marcus O. W.;Groesgen, Sven;Hartmann, Tobias
通讯作者：
Hartmann, Tobias
影响因子：
4.8
作者：
Chan, Robin B.;Oliveira, Tiago G.;Di Paolo, Gilbert
通讯作者：
Di Paolo, Gilbert