Factors that determine recovery of left ventricular function after thrombolysis in patients with acute myocardial infarction.
Factors that determine recovery of left ventricular function after thrombolysis in patients with acute myocardial infarction.
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急性心肌梗死患者溶栓后左心室功能恢复的决定因素
DOI：
10.1161/01.cir.71.6.1121
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发表时间：
1985
期刊：
影响因子：
37.8
通讯作者：
E. Bolson
中科院分区：
文献类型：
--
作者：
Florence H. Sheehan;Detlef G. Mathey;Joachim Schofer;H. Dodge;E. Bolson
本文对47例急性心肌梗死患者经冠脉内链激酶再灌注后冠状动脉及心室造影进行定量分析，以探讨影响再灌注后局部左室功能恢复的因素。梗死区的运动功能减退通过中心线法测量，并以与正常的标准差（SD）表示。定量测量冠状动脉狭窄程度。溶栓后，最小狭窄直径大于0.4 mm的患者的运动功能减退比严重残余狭窄患者的改善更显著，即，狭窄产生的最小直径为0.4 mm或更小（1.0 +/- 1.3 SD/弦，n = 31，vs 0.0 +/- 0.9 SD/弦，n = 7; p <0.05）。在2小时内接受溶栓治疗的患者中，运动功能减退的改善程度大于随后接受治疗的患者（2.1 +/- 1.1，n = 8，vs 0.7 +/- 1.0 SD/弦，n = 28; p小于0.001）。这些结果表明，单独的血管造影再灌注可能是不够的：再灌注必须提供足够的流量，并尽早实现挽救心肌功能。
The coronary and ventricular angiograms of 47 patients with acute myocardial infarction in whom reperfusion was achieved by intracoronary streptokinase were quantitatively analyzed to determine the factors that affect recovery of regional left ventricular function after reperfusion. Hypokinesis in the infarct region was measured by the centerline method and expressed in terms of standard deviations (SDs) from normal. Severity of coronary artery stenosis was measured quantitatively. Hypokinesis showed more significant improvement after thrombolysis in patients with minimum stenosis diameter of greater than 0.4 mm than in those with severe residual stenosis, i.e., stenosis producing a minimum diameter of 0.4 mm or less (1.0 +/- 1.3 SD/chord, n = 31, vs 0.0 +/- 0.9 SD/chord, n = 7; p less than .05). Improvement in hypokinesis was greater in patients who received thrombolytic therapy within 2 hr than in those treated later (2.1 +/- 1.1, n = 8, vs 0.7 +/- 1.0 SD/chord, n = 28; p less than .001). These results indicate that angiographic reperfusion alone may not be sufficient: reperfusion must provide adequate flow and be achieved early to salvage myocardial function.
急性心肌梗死冠状动脉内输注链激酶后受损心肌的功能改善。
DOI：
10.1172/jci110987
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Stack,RS;Phillips3rd,HR;Grierson,DS;Behar,VS;Kong,Y;Peter,RH;Swain,JL;GreenfieldJr,JC
通讯作者：
GreenfieldJr,JC
DOI：
10.1056/nejm198211043071904
发表时间：
1982-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Stampfer;S. Goldhaber;S. Yusuf;R. Peto;C. Hennekens
通讯作者：
M. Stampfer;S. Goldhaber;S. Yusuf;R. Peto;C. Hennekens
在心肌梗死发展过程中，冠状动脉内给予链激酶可持续改善左心室功能和死亡率。
影响因子：
37.8
作者：
Smalling,RW;Fuentes,F;Matthews,MW;Freund,GC;Hicks,CH;Reduto,LA;Walker,WE;Sterling,RP;Gould,KL
通讯作者：
Gould,KL