The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms *
The interferon‐γ‐induced protein 10/CXCR3 axis is associated with human herpesvirus‐6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms *
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干扰素 γ 诱导的蛋白 10/CXCR3 轴与人疱疹病毒 6 的再激活以及嗜酸性粒细胞增多和全身症状的药物反应后遗症的发生有关*
DOI：
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发表时间：
2020
影响因子：
10.3
通讯作者：
C. Chu
中科院分区：
文献类型：
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作者：
C.‐W. Yang;Y. Cho;Yi;Shao;K. Chen;C. Chu
伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）是由药物诱导的免疫反应引起的一种病症。此前的报道发现CXCL10，也称为干扰素-γ诱导蛋白（IP）-10，可能参与皮肤药物不良反应的发病机制。然而，IP-10 在 DRESS 和 Stevens-Johnson 综合征 (SJS)/中毒性表皮坏死松解症 (TEN) 中的确切作用仍不清楚。
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a condition caused by a drug‐induced immune response. Previous reports have found that CXCL10, also known as interferon‐γ‐induced protein (IP)‐10, may participate in the pathogenesis of cutaneous adverse drug reactions. However, the exact role of IP‐10 in DRESS and Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) has remained unknown.
影响因子：
3.7
作者：
Groom JR;Luster AD
通讯作者：
Luster AD