Searching for a photocycle of the cryptochrome photoreceptors.
Searching for a photocycle of the cryptochrome photoreceptors.
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DOI:
10.1016/j.pbi.2010.09.005
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发表时间:
2010-10
影响因子:
9.5
通讯作者:
Lin C
中科院分区:
文献类型:
--
作者:
Liu B;Liu H;Zhong D;Lin C
The initial photochemistry of plant cryptochromes has been extensively investigated in recent years. It is hypothesized that cryptochrome photoexcitation involves a Trp-triad-dependent photoreduction. According to this hypothesis, cryptochromes in the resting state contain oxidized FAD; light triggers a sequential electron transfer from three tryptophan residues to reduce FAD to a neutral semiquinone (FADH•); FADH• is the presumed signaling state and it is re-oxidized to complete the photocycle. However, this photoreduction hypothesis is currently under debate. An alternative model argues that the initial photochemistry of cryptochromes involves a photolyase-like cyclic electron shuttle without a bona fide redox reaction mediated by the Trp-triad residues, leading to conformational changes, signal propagation, and physiological responses.
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