Searching for a photocycle of the cryptochrome photoreceptors.

Searching for a photocycle of the cryptochrome photoreceptors.
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DOI:
10.1016/j.pbi.2010.09.005
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发表时间:
2010-10
影响因子:
9.5
通讯作者:
Lin C
Lin C
中科院分区:
生物学2区
文献类型:
--
作者:
Liu B;Liu H;Zhong D;Lin C

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近年来,植物隐花色素的初始光化学反应得到了广泛的研究。据推测,隐花色素的光激发涉及色氨酸三联体依赖的光还原。根据这一假说,处于静止状态的隐花色素含有氧化的FAD;光触发三个色氨酸残基的顺序电子转移,将FAD还原为中性半醌(FADH·); FADH·是假定的信号状态,它被重新氧化以完成光循环。然而,这种光还原假说目前仍有争议。另一种模型认为,隐花色素的初始光化学涉及一个光解酶样的循环电子穿梭没有真正的氧化还原反应介导的色氨酸-三联体残基,导致构象变化,信号传播和生理反应。
The initial photochemistry of plant cryptochromes has been extensively investigated in recent years. It is hypothesized that cryptochrome photoexcitation involves a Trp-triad-dependent photoreduction. According to this hypothesis, cryptochromes in the resting state contain oxidized FAD; light triggers a sequential electron transfer from three tryptophan residues to reduce FAD to a neutral semiquinone (FADH•); FADH• is the presumed signaling state and it is re-oxidized to complete the photocycle. However, this photoreduction hypothesis is currently under debate. An alternative model argues that the initial photochemistry of cryptochromes involves a photolyase-like cyclic electron shuttle without a bona fide redox reaction mediated by the Trp-triad residues, leading to conformational changes, signal propagation, and physiological responses.
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