Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion.
Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion.
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DOI：
10.3389/fonc.2020.569985
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发表时间：
2020
影响因子：
4.7
通讯作者：
Machado HL
中科院分区：
文献类型：
--
作者：
Ibrahim AM;Moss MA;Gray Z;Rojo MD;Burke CM;Schwertfeger KL;Dos Santos CO;Machado HL
骨髓细胞异质性在乳腺癌中的研究仍然很少，尤其是在恶性肿瘤前。在这里，我们使用单细胞RNA测序来表征小鼠侵袭前病变与局部侵袭病变中巨噬细胞的多样性。研究人员发现了几个具有不同转录谱的巨噬细胞亚群，其中两个亚群与稳态巨噬细胞相似。虽然所有亚群都表达促肿瘤基因，但许多亚群表达促炎基因，这与肿瘤相关巨噬细胞的报道不同。骨髓细胞的基因谱在早期和晚期的恶性肿瘤前期是相似的，尽管一些亚群的扩增发生。这些结果揭示了巨噬细胞在早期进展中的异质性，并可能为针对巨噬细胞的早期干预策略提供见解。
Myeloid cell heterogeneity remains poorly studied in breast cancer, and particularly in premalignancy. Here, we used single cell RNA sequencing to characterize macrophage diversity in mouse pre-invasive lesions as compared to lesions undergoing localized invasion. Several subpopulations of macrophages with transcriptionally distinct profiles were identified, two of which resembled macrophages in the steady state. While all subpopulations expressed tumor-promoting genes, many of the populations expressed pro-inflammatory genes, differing from reports in tumor-associated macrophages. Gene profiles of the myeloid cells were similar between early and late stages of premalignancy, although expansion of some subpopulations occurred. These results unravel macrophage heterogeneity in early progression and may provide insight into early intervention strategies that target macrophages.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Date, Dipali;Das, Riku;Mahabeleshwar, Ganapati H.
通讯作者：
Mahabeleshwar, Ganapati H.
影响因子：
5.8
作者：
Angerer, Philipp;Haghverdi, Laleh;Buettner, Florian
通讯作者：
Buettner, Florian
KLF6 在肠道炎症的发病机制中有助于骨髓细胞的可塑性。
影响因子：
8
作者：
Goodman WA;Omenetti S;Date D;Di Martino L;De Salvo C;Kim GD;Chowdhry S;Bamias G;Cominelli F;Pizarro TT;Mahabeleshwar GH
通讯作者：
Mahabeleshwar GH
DOI：
10.1158/1541-7786.mcr-12-0275
发表时间：
2012-10
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Bohrer LR;Schwertfeger KL
通讯作者：
Schwertfeger KL