Novel roles of peroxiredoxins in inflammation, cancer and innate immunity.
Novel roles of peroxiredoxins in inflammation, cancer and innate immunity.
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DOI：
10.3164/jcbn.11-109
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发表时间：
2012-03
影响因子：
2.4
通讯作者：
Yanagawa T
中科院分区：
文献类型：
--
作者：
Ishii T;Warabi E;Yanagawa T
过氧化物酶具有硫氧还蛋白或谷胱甘肽过氧化物酶和分子伴侣样活性，从而保护细胞免受氧化损伤。然而，最近的研究揭示了过氧化物酶在基因表达和炎症相关的生物反应，如组织修复，寄生虫感染和肿瘤进展中的额外功能。值得注意的是，过氧化物氧还蛋白1（主要的哺乳动物过氧化物氧还蛋白家族蛋白）直接与细胞核中的转录因子如c-Myc和NF-κB相互作用。此外，在用TGF-β和其他细胞因子刺激后，过氧化物氧还蛋白1从一些细胞分泌，因此存在于血浆和体液中。目前认为过氧化物氧还蛋白1是一种与Toll样受体4相互作用的促炎因子，通过Toll样受体4激活NF-κB等信号通路，引起炎症反应。一些癌细胞释放peroxiredoxin 1，以刺激toll样受体4介导的信号传导，促进其进展。有趣的是，在原生动物和蠕虫中表达的过氧化物酶可能部分地通过Toll样受体4调节宿主的免疫应答，以使其在宿主中存活和发展。已知细胞外过氧化物氧还蛋白1和过氧化物氧还蛋白2增强自然杀伤细胞活性并抑制细胞中的病毒复制。Peroxiredoxin 1缺陷小鼠显示出降低的抗氧化活性，但在某些病理生理条件下也表现出抑制的组织炎症反应。过氧化物酶在炎症、癌症和先天免疫中的新功能是本文的重点。
Peroxiredoxins possess thioredoxin or glutathione peroxidase and chaperone-like activities and thereby protect cells from oxidative insults. Recent studies, however, reveal additional functions of peroxiredoxins in gene expression and inflammation-related biological reactions such as tissue repair, parasite infection and tumor progression. Notably, peroxiredoxin 1, the major mammalian peroxiredoxin family protein, directly interacts with transcription factors such as c-Myc and NF-κB in the nucleus. Additionally, peroxiredoxin 1 is secreted from some cells following stimulation with TGF-β and other cytokines and is thus present in plasma and body fluids. Peroxiredoxin 1 is now recognized as one of the pro-inflammatory factors interacting with toll-like receptor 4, which triggers NF-κB activation and other signaling pathways to evoke inflammatory reactions. Some cancer cells release peroxiredoxin 1 to stimulate toll-like receptor 4-mediated signaling for their progression. Interestingly, peroxiredoxins expressed in protozoa and helminth may modulate host immune responses partly through toll-like receptor 4 for their survival and progression in host. Extracellular peroxiredoxin 1 and peroxiredoxin 2 are known to enhance natural killer cell activity and suppress virus-replication in cells. Peroxiredoxin 1-deficient mice show reduced antioxidant activities but also exhibit restrained tissue inflammatory reactions under some patho-physiological conditions. Novel functions of peroxiredoxins in inflammation, cancer and innate immunity are the focus of this review.
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发表时间：
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影响因子：
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发表时间：
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