Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells.

Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells.
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DOI:
10.1039/c3cc49003c
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发表时间:
2014-03-21
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Tan W
Tan W
中科院分区:
其他
文献类型:
--
作者:
Huang F;You M;Chen T;Zhu G;Liang H;Tan W

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制备并表征了一种基于适体-脂质-聚(丙交酯-羟基乙酸)杂化纳米粒的药物递送系统。该杂交体可以以高特异性和效率将具有不同溶解度特征和不同抗癌机制的两种不同药物共递送至靶向癌细胞。
A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. The hybrid can co-deliver two different drugs with distinct solubility characteristics and different anticancer mechanisms to target cancer cells with high specificity and efficiency.
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