Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine.
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine.
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DOI：
10.4161/adip.29853
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发表时间：
2015-01
期刊：
影响因子：
3.3
通讯作者：
Christian M
中科院分区：
文献类型：
--
作者：
Christian M
棕色脂肪细胞通过表达一组独特的基因来帮助维持体温，这些基因有助于细胞代谢活动，包括依赖解偶联蛋白1的产热作用。棕色脂肪组织(BAT)的能量消耗与白色脂肪组织(WAT)形成鲜明对比，白色脂肪组织是人体储存能量的主要部位。然而，脂肪组织是高度动态的，在冷暴露时，WAT发生了深刻的变化，由于存在白褐色(BRITE)脂肪细胞，导致了蝙蝠样的表型。在我们最近的报告中，转录图谱被用来确定导致褐化过程的基因表达变化以及BAT和WAT之间的内在差异。NeuRegin 4被归类为一种冷诱导的BAT基因，编码一种脂肪因子，在脂肪细胞和神经细胞之间传递信号，并可能在增加脂肪组织对寒冷的神经反应中发挥作用。
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis. The dissipation of energy in brown adipose tissue (BAT) is in stark contrast to white adipose tissue (WAT) which is the body's primary site of energy storage. However, adipose tissue is highly dynamic and upon cold exposure profound changes occur in WAT resulting in a BAT-like phenotype due to the presence of brown-in-white (BRITE) adipocytes. In our recent report, transcription profiling was used to identify the gene expression changes that underlie the browning process as well as the intrinsic differences between BAT and WAT. Neuregulin 4 was categorized as a cold-induced BAT gene encoding an adipokine that signals between adipocytes and nerve cells and likely to have a role in increasing adipose tissue innervation in response to cold.
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影响因子：
5.2
作者：
Hudak CS;Sul HS
通讯作者：
Sul HS
影响因子：
15.9
作者：
Croteau, W;Davey, JC;StGermain, DL
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