Cardiovascular risk factors from childhood and midlife physical function: The Bogalusa Heart Study.
Cardiovascular risk factors from childhood and midlife physical function: The Bogalusa Heart Study.
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童年和中年身体机能的心血管危险因素：Bogalusa 心脏研究
DOI：
10.1016/j.exger.2020.110947
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发表时间：
2020-07-15
影响因子：
3.9
通讯作者：
Bazzano LA
中科院分区：
文献类型：
--
作者：
Du T;Fernandez C;Barshop R;Guralnik J;Bazzano LA
生命过程模型很少应用于身体功能。我们试图研究儿童期心血管危险因素（CVRF）累积负担对中年身体功能的影响。这项纵向研究包括718名参与者（随访时年龄为37至56岁），他们在儿童期至少接受了4次CVRF检查，成年期至少接受了2次CVRF检查，随访时间为39年。我们在2013年至2016年期间使用短期身体功能组合（SPPB）、6分钟步行试验（6MWT）和握力评估了身体功能。使用生长曲线下面积（AUC）作为儿童期CVRF累积暴露量的指标。儿童期HDL-胆固醇水平AUC与SPPB评分呈正相关。体重指数（BMI）和甘油三酯（TG）的AUC水平与6MWT呈负相关。收缩压/舒张压（BP）的AUC水平越高，预示着握力越差。前四分位数中的儿童期CVRF数量（包括BMI和TG的AUC水平）与6MWT呈负相关，并在校正成年期CVRF后保持显著性。儿童期CVRF的累积负担与中年期身体功能较差相关，与成年期CVRF无关。
Life-course models have been infrequently applied to physical function. We sought to examine the effects of the cumulative burden of cardiovascular risk factors (CVRFs) from childhood on physical function in midlife. This longitudinal study consisted of 718 participants (aged 37 to 56 years at follow-up) who were examined for CVRFs at least four times during childhood and at least twice in adulthood, with 39 years of follow-up. We assessed physical function in 2013–2016 with the Short Physical Performance Battery (SPPB), 6-minute walking test (6MWT), and handgrip strength. The area under the growth curve (AUC) was used as a measure of cumulative exposure to CVRFs during childhood. AUC of HDL-cholesterol levels in childhood were positively associated with SPPB score. AUC levels of body mass index (BMI) and triglycerides (TG) were inversely associated with 6MWT. Higher AUC levels of systolic/diastolic blood pressure (BP) predicted poorer hand grip strength. The number of childhood CVRFs in the top quartile, including AUC levels of BMI and TG, were inversely associated with 6MWT and remained significant after adjustment for the adulthood CVRFs. Cumulative burden of CVRFs from childhood were associated with worse physical function in midlife independent of adulthood CVRFs.
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影响因子：
7.7
作者：
McQuaid SE;Hodson L;Neville MJ;Dennis AL;Cheeseman J;Humphreys SM;Ruge T;Gilbert M;Fielding BA;Frayn KN;Karpe F
通讯作者：
Karpe F
影响因子：
7.7
作者：
Gustafson B;Hammarstedt A;Hedjazifar S;Smith U
通讯作者：
Smith U
影响因子：
4.9
作者：
Houston, D. K.;Ding, J.;Kritchevsky, S. B.
通讯作者：
Kritchevsky, S. B.
影响因子：
24
作者：
Passantino, Andrea;Lagioia, Rocco;Scrutinio, Domenico
通讯作者：
Scrutinio, Domenico
与年龄和疾病相关的肌肉损失：糖尿病、肥胖和其他疾病的影响。
影响因子：
44.5
作者：
Kalyani, Rita Rastogi;Corriere, Mark;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi