Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.
Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.
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DOI：
10.1016/j.neuropharm.2011.01.020
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发表时间：
2011-06
影响因子：
4.7
通讯作者：
Krystal, John H.
中科院分区：
文献类型：
--
作者：
Cosgrove, Kelly P.;Esterlis, Irina;Mason, Graeme F.;Bois, Frederic;O'Malley, Stephanie S.;Krystal, John H.
本文综述了尼古丁和烟草烟雾深刻调节酒精对γ-氨基丁酸（GABA）神经元功能影响的证据，特别是gabaa -苯二氮卓类受体（GABAA-BZR）。本文的重点是最近的神经影像学证据在临床前模型和临床实验。首先，我们回顾了涉及酒精在GABAA-BZR中的作用的研究结果，并讨论了急性和长期酒精戒断期间GABAA-BZR可用性的变化。其次，我们讨论了临床前证据，表明尼古丁通过神经元尼古丁乙酰胆碱受体的主要作用间接影响GABA神经元功能。第三，我们在研究酒精依赖吸烟者和非吸烟者的GABA水平和GABAA-BZRs的研究中展示了这些证据是如何集中的，这表明吸烟会减弱戒酒期间发生的化学变化。基于对文献的全面回顾，我们假设吸烟使酒精依赖个体在急性饮酒周期中通常发生的GABA水平变化最小化。因此，在戒酒期间，持续吸烟降低了与戒断相关的氨基丁酸化学变化的严重程度。
This paper reviews evidence suggesting that nicotine and tobacco smoke profoundly modulate the effects of alcohol on γ-aminobutyric acid (GABA) neuronal function, specifically at the GABAA-benzodiazepine receptor (GABAA-BZR). The focus of this paper is on recent neuroimaging evidence in preclinical models as well as clinical experiments. First, we review findings implicating the role of alcohol at the GABAA-BZR and discuss the changes in GABAA-BZR availability during acute and prolonged alcohol withdrawal. Second, we discuss preclinical evidence that suggests nicotine affects GABA neuronal function indirectly by a primary action at neuronal nicotinic acetylcholine receptors. Third, we show how this evidence converges in studies that examine GABA levels and GABAA-BZRs in alcohol-dependent smokers and nonsmokers, suggesting that tobacco smoking attenuates the chemical changes that occur during alcohol withdrawal. Based on a comprehensive review of literature, we hypothesize that tobacco smoking minimizes the changes in GABA levels that typically occur during the acute cycles of drinking in alcohol-dependent individuals. Thus, during alcohol withdrawal, the continued tobacco smoking decreases the severity of the withdrawal-related changes in GABA chemistry.
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影响因子：
5.3
作者：
Ariwodola, OJ;Weiner, JL
通讯作者：
Weiner, JL
影响因子：
2.8
作者：
Danel, T;Jeanson, R;Touitou, Y
通讯作者：
Touitou, Y
影响因子：
2.7
作者：
Balfour, DJK;Wright, AE;Birrell, CE
通讯作者：
Birrell, CE
DOI：
10.1002/ajmg.b.30091
发表时间：
2004-08-15
影响因子：
2.8
作者：
Covault, J;Gelernter, J;Kranzler, HR
通讯作者：
Kranzler, HR
DOI：
10.1016/s1054-3589(08)60072-1
发表时间：
1997-01-01
期刊：
Advances in pharmacology (San Diego, Calif.)
影响因子：
--
作者：
Colquhoun, L M;Patrick, J W
通讯作者：
Patrick, J W