Physiological FAP-activation in a postpartum woman observed in oncological FAPI-PET/CT.
Physiological FAP-activation in a postpartum woman observed in oncological FAPI-PET/CT.
复制标题
在肿瘤学FAPI-PET/CT中观察到的产后妇女的生理FAP激活。
DOI：
10.1007/s00259-021-05203-8
复制
发表时间：
2021-06
影响因子：
9.1
通讯作者：
Giesel FL
中科院分区：
文献类型：
--
作者：
Dendl K;Koerber SA;Adeberg S;Röhrich M;Kratochwil C;Haberkorn U;Giesel FL
成纤维细胞激活蛋白(FAP)是一种由肿瘤相关成纤维细胞过度表达的II型跨膜丝氨酸蛋白酶[1]。然而，在与组织重建相关的非恶性过程中也可以观察到高表达，例如伤口愈合和导致纤维化的疾病[2]。我们的影像是一位29岁的女性患者，右咽旁间隙的腺样囊性癌伴有颅骨侵犯。该肿瘤于2018年12月首次被诊断，随后经组织学证实，初步分类为CT4 cN0 cM0。在计划放射治疗的范围内，进行了(68Ga-FAPI-46)PET/CT扫描，发现腺样囊性癌(A)，SUVmax分别为17.3。令人惊讶的是，两个乳房的实质都被很好地描绘出来，右侧的SUVmax分别为4.1，左侧为3.5(B)。子宫内膜的SUVmax为25.7，如c所示。甲状腺的摄取也增加了(SUV6.3)。
Fibroblast activation protein (FAP) is a type II transmembrane serine protease overexpressed by cancer-associated fibroblasts [1]. However, high expression can also be observed in nonmalignant processes associated with tissue remodeling such as wound healing and diseases leading to fibrosis [2]. Our image presents a 29-year-old female patient with adenoid cystic carcinoma in the right parapharyngeal space with skull infiltration. The tumor was first diagnosed in 12/2018 and subsequently histologically confirmed with an initial classification of cT4 cN0 cM0. Within the scope of planning radiation therapy, a (68Ga-FAPI-46) PET/CT was performed presenting a clear finding of the adenoid cystic carcinoma (a) with a SUVmax of 17.3, respectively. Surprisingly, the parenchyma in both breasts was well depicted with a SUVmax of 4.1 in the right and 3.5 in the left, respectively (b). The endometrium remarkably demonstrated a SUVmax of 25.7 as highlighted in c. Uptake in the thyroid (SUV 6.3) was also increased.
登录
查看更多内容
影响因子：
3.5
作者：
MIZUKAMI, Y;MICHIGISHI, T;TAKAZAKURA, E
通讯作者：
TAKAZAKURA, E
影响因子：
4
作者：
Gao, Ming-Qing;Kim, Baek Gil;Cho, Nam Hoon
通讯作者：
Cho, Nam Hoon
影响因子：
5.5
作者：
Heller, Samantha L.;Lin, Leng Leng Young;Gao, Yiming
通讯作者：
Gao, Yiming
DOI：
10.1073/pnas.85.9.3110
发表时间：
1988-05-01
影响因子：
11.1
作者：
RETTIG, WJ;GARINCHESA, P;OLD, LJ
通讯作者：
OLD, LJ