The neurophysiology of biological motion perception in schizophrenia.
The neurophysiology of biological motion perception in schizophrenia.
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DOI：
10.1002/brb3.303
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发表时间：
2015-01
影响因子：
3.1
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Jahshan, Carol;Wynn, Jonathan K.;Mathis, Kristopher I.;Green, Michael F.
识别人类生物运动的能力是精神分裂症患者社会认知的一个基本方面。然而，对精神分裂症中受损的生物运动知觉的神经基质知之甚少。在当前的研究中，我们评估了精神分裂症患者对人类和非人类运动的事件相关电位（ERPs）。24名精神分裂症患者和18名健康对照者在完成生物运动任务的同时记录脑电图（EEG）。受试者观看了包含100%、85%或70%生物运动的点光动画片段，并被要求判断片段是否类似于人类或非人类的运动。检测三个erp: P1， N1和晚期正电位（LPP）。在行为上，与健康对照组相比，在100%和85%的情况下，精神分裂症受试者识别出的人类运动刺激明显减少。在神经水平上，P1在精神分裂症组中减少，但在两组之间没有差异。N1无组间差异，但在70%的情况下，两组的N1均最大。LPP存在条件×组相互作用：健康对照组的LPP为100%，而生物运动为85%和70%；精神分裂症受试者的情况没有差异。与先前的研究结果一致，精神分裂症受试者识别生物运动的能力受损。脑电结果显示，生物运动不影响视觉加工的最早阶段（P1）。尽管精神分裂症受试者与健康对照者表现出相同的N1结果模式，但他们在后期阶段（LPP）受损，反映了在生物和非生物运动刺激下识别人类形态的功能障碍。
The ability to recognize human biological motion is a fundamental aspect of social cognition that is impaired in people with schizophrenia. However, little is known about the neural substrates of impaired biological motion perception in schizophrenia. In the current study, we assessed event-related potentials (ERPs) to human and nonhuman movement in schizophrenia. Twenty-four subjects with schizophrenia and 18 healthy controls completed a biological motion task while their electroencephalography (EEG) was simultaneously recorded. Subjects watched clips of point-light animations containing 100%, 85%, or 70% biological motion, and were asked to decide whether the clip resembled human or nonhuman movement. Three ERPs were examined: P1, N1, and the late positive potential (LPP). Behaviorally, schizophrenia subjects identified significantly fewer stimuli as human movement compared to healthy controls in the 100% and 85% conditions. At the neural level, P1 was reduced in the schizophrenia group but did not differ among conditions in either group. There were no group differences in N1 but both groups had the largest N1 in the 70% condition. There was a condition × group interaction for the LPP: Healthy controls had a larger LPP to 100% versus 85% and 70% biological motion; there was no difference among conditions in schizophrenia subjects. Consistent with previous findings, schizophrenia subjects were impaired in their ability to recognize biological motion. The EEG results showed that biological motion did not influence the earliest stage of visual processing (P1). Although schizophrenia subjects showed the same pattern of N1 results relative to healthy controls, they were impaired at a later stage (LPP), reflecting a dysfunction in the identification of human form in biological versus nonbiological motion stimuli.
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