Nanoparticles of esterified polymalic acid for controlled anticancer drug release.
Nanoparticles of esterified polymalic acid for controlled anticancer drug release.
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DOI：
10.1002/mabi.201400124
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发表时间：
2014-09
影响因子：
4.6
通讯作者：
Munoz-Guerra, Sebastian
中科院分区：
文献类型：
--
作者：
Lanz-Landazuri, Alberto;Portilla-Arias, Jose;Martinez de Ilarduya, Antxon;Garcia-Alvarez, Montserrat;Holler, Eggehard;Ljubimova, Julia;Munoz-Guerra, Sebastian
Esterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates capable to form nanoparticles (100–350 nm). Degradation under physiological conditions takes place with release of malic acid and the corresponding alcohol as unique degradation products. The anticancer drugs Temozolomide and Doxorubicin are encapsulated in nanoparticles with efficiency of 17 and 37%, respectively. In vitro drug release assays show that Temozolomide is almost completely discharged in a few hours whereas Doxorubicin is steadily released along several days. Drug-loaded nano-particles show remarkable effectiveness against cancer cells. Partially ethylated poly(malic acid) nano-particles are those showing the highest cellular uptake.
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DOI：
10.1016/j.jconrel.2013.06.001
发表时间：
2013-11-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
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作者：
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Ljubimova JY
影响因子：
3.7
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Ljubimova, Julia Y.
影响因子：
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作者：
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通讯作者：
Margaritis, Argyrios
DOI：
10.1073/pnas.1003919107
发表时间：
2010-10-19
影响因子：
11.1
作者：
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通讯作者：
Ljubimova, Julia Y.
影响因子：
10.8
作者：
Zambaux, MF;Bonneaux, F;Vigneron, C
通讯作者：
Vigneron, C