Innate lymphoid cells (ILC) in SARS-CoV-2 infection.

Innate lymphoid cells (ILC) in SARS-CoV-2 infection.
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DOI:
10.1016/j.mam.2021.101008
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发表时间:
2021-08
影响因子:
10.6
通讯作者:
Sambhara S
Sambhara S
中科院分区:
医学1区
文献类型:
--
作者:
Kumar A;Cao W;Endrias K;Kuchipudi SV;Mittal SK;Sambhara S

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先天性类淋巴细胞(inate apnephoid Cells,ILC)是一类先天性免疫细胞,在哺乳动物宿主体内形成抵御内部或外部非生物和生物挑战的第一道防线。由于它们存在于淋巴和非淋巴组织中,它们通过直接杀伤或通过分泌调节适应性免疫应答的细胞因子参与清除病原体。有越来越多的证据表明,这些细胞在清除病毒感染方面很重要;因此,了解它们在严重急性呼吸综合征冠状病毒(SARS-CoV-2)引起的疾病的解决或恶化中的作用至关重要。本文综述了近年来有关ILCs在SARS-CoV-2感染中的作用的研究进展。
Innate Lymphoid Cells (ILCs) are a class of innate immune cells that form the first line of defense against internal or external abiotic and biotic challenges in the mammalian hosts. As they reside in both the lymphoid and non-lymphoid tissues, they are involved in clearing the pathogens through direct killing or by secretion of cytokines that modulate the adaptive immune responses. There is burgeoning evidence that these cells are important in clearing viral infections; therefore, it is critical to understand their role in the resolution or exacerbation of the disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this review, we summarize the recent findings related to ILCs in response to SARS-CoV-2 infections.
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