LC-ED with an Acetylene Black–Dihexadecyl Hydrogen Phosphate Composite Film-Modified Electrode for in Vivo Analysis of Thiols in Rat Striatal Microdialysate
LC-ED with an Acetylene Black–Dihexadecyl Hydrogen Phosphate Composite Film-Modified Electrode for in Vivo Analysis of Thiols in Rat Striatal Microdialysate
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采用乙炔黑-二十六烷基磷酸氢复合膜修饰电极的 LC-ED 用于大鼠纹状体微透析液中硫醇的体内分析
DOI：
10.1365/s10337-010-1682-y
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发表时间：
2010
期刊：
影响因子：
1.7
通讯作者：
Xiaokun Li
中科院分区：
文献类型：
--
作者：
Li Lin;Hongchang Gao;Dan;Miaomiao Gao;Min Xiao;Shulin Yang;Xiaokun Li
Liquid chromatography with electrochemical detection (LC-ED), coupled with in vivo microdialysis sampling, has been used for analysis of thiols. An acetylene black–dihexadecyl hydrogen phosphate (AB–DHP) composite film-modified electrode was used as working electrode. The AB–DHP-modified electrode enabled efficient electrocatalytic oxidation of l-cysteine (l-Cys) and glutathione (GSH) with relatively high sensitivity, stability, and longevity. The peak currents of l-Cys and GSH were linear in the concentrations ranges 2.0 × 10−7–2.0 × 10−4 and 3.0 × 10−7–5.0 × 10−4 mol L−1, respectively, with calculated detection limits (S/N = 3) of 1.0 × 10−7 and 2.0 × 10−7 mol L−1, respectively. The method has been successfully used to measure the amounts of l-Cys and GSH in striatal microdialysate of freely moving rats.
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影响因子：
56.9
作者：
AMES, BN
通讯作者：
AMES, BN
影响因子：
5.8
作者：
Bharath, S;Hsu, M;Andersen, JK
通讯作者：
Andersen, JK
DOI：
10.1016/s0731-7085(02)00594-0
发表时间：
2003-02-26
影响因子：
3.4
作者：
Guan, XM;Hoffman, B;Matthees, DP
通讯作者：
Matthees, DP
影响因子：
56.9
作者：
OLNEY, JW;ZORUMSKI, C;LABRUYERE, J
通讯作者：
LABRUYERE, J