Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
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DOI：
10.1038/ncomms3312
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发表时间：
2013
影响因子：
16.6
通讯作者：
Del Rio-Tsonis, Katia
中科院分区：
文献类型：
--
作者：
Haynes, Tracy;Luz-Madrigal, Agustin;Reis, Edimara S.;Ruiz, Nancy P. Echeverri;Grajales-Esquivel, Erika;Tzekou, Apostolia;Tsonis, Panagiotis A.;Lambris, John D.;Del Rio-Tsonis, Katia
识别脊椎动物组织再生的起始信号是再生生物学的主要挑战之一。迄今为止的许多研究表明，某些生长因子具有关键作用。在这里，我们表明，补体片段C3 a是足以诱导胚胎鸡视网膜的干/祖细胞在眼睛中，独立的成纤维细胞生长因子受体信号转导的完全再生。相反，C3 a通过STAT 3激活诱导视网膜再生，这反过来又激活损伤和炎症反应因子IL-6，IL-8和TNF-α。这种激活阐述了与视网膜干细胞和祖细胞相关的基因Wnt 2b、Six 3和Sox 2的调节。因此，我们的研究结果建立了基于损伤和炎症信号的视网膜再生机制。此外，我们的研究结果表明，补体过敏毒素的独特功能，涉及这些分子的诱导和视网膜的完全再生，开辟了新的途径，在该领域的实验。 补体系统的成分已被证明可以促进肝再生。Haynes等证明补体片段C3 a可以通过激活STAT 3和其他下游信号传导途径诱导胚胎鸡视网膜从睫状缘的干细胞和祖细胞再生。
Identifying the initiation signals for tissue regeneration in vertebrates is one of the major challenges in regenerative biology. Much of the research thus far has indicated that certain growth factors have key roles. Here we show that complement fragment C3a is sufficient to induce complete regeneration of the embryonic chick retina from stem/progenitor cells present in the eye, independent of fibroblast growth factor receptor signaling. Instead, C3a induces retina regeneration via STAT3 activation, which in turn activates the injury- and inflammation-responsive factors, IL-6, IL-8 and TNF-α. This activation sets forth regulation of Wnt2b, Six3 and Sox2, genes associated with retina stem and progenitor cells. Thus, our results establish a mechanism for retina regeneration based on injury and inflammation signals. Furthermore, our results indicate a unique function for complement anaphylatoxins that implicate these molecules in the induction and complete regeneration of the retina, opening new avenues of experimentation in the field. Components of the complement system have been shown to promote liver regeneration. Haynes et al. demonstrate that the complement fragment C3a can induce regeneration of the embryonic chick retina from stem and progenitor cells of the ciliary margin via activation of STAT3 and other downstream signalling pathways.
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影响因子：
2.7
作者：
PARK, CM;HOLLENBERG, MJ
通讯作者：
HOLLENBERG, MJ
影响因子：
3.4
作者：
Kassen, Sean C.;Thummel, Ryan;Hyde, David R.
通讯作者：
Hyde, David R.
影响因子：
2.9
作者：
Liang, Yajie;Li, Shurong;Su, Bingyin
通讯作者：
Su, Bingyin
影响因子：
20.3
作者：
Langer, Harald F.;Chung, Kyoung-Jin;Chavakis, Triantafyllos
通讯作者：
Chavakis, Triantafyllos
影响因子：
15.9
作者：
He, Songqing;Atkinson, Carl;Tomlinson, Stephen
通讯作者：
Tomlinson, Stephen