Mechanisms Underlying Spatial Representation Revealed through Studies of Hemispatial Neglect
Mechanisms Underlying Spatial Representation Revealed through Studies of Hemispatial Neglect
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通过半侧空间忽视研究揭示空间表征的潜在机制
DOI：
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发表时间：
2002
影响因子：
3.2
通讯作者：
R. Kass
中科院分区：
文献类型：
--
作者：
M. Behrmann;T. Ghiselli;J. Sweeney;Ilaria Di Matteo;R. Kass
通过比较左半球忽视患者与非神经控制受试者的行为，研究了介导空间位置编码的表征。为了确定用于定义左右的空间坐标系统，我们测量了出现在相对于眼睛中线、头部或躯干矢状中平面的相对左或右58,108和158处的目标的眼球运动。在基线条件下，在各种自我中心中线都与环境中线对齐的情况下，与对照组相比，患者对左侧目标的扫视比对右侧目标的扫视慢得多。当躯干或头部旋转时，中线与最外围的位置对齐，而眼睛保持与环境中线对齐时，结果与基线条件没有差异。然而，当眼睛旋转且中线与周围位置对齐时，跳回反应时间（SRT）与基线有显著差异，特别是当眼睛向右旋转时。这些发现表明，目标位置是相对于当前凝视位置（以眼为中心）进行编码的，并且这种以眼为中心的编码受到眼眶位置（眼在头上的信号）的调节。这些发现与现有的神经生理学研究结果相吻合，并进一步阐明了由人类顶叶皮层介导的空间表征。
The representations that mediate the coding of spatial position were examined by comparing the behavior of patients with left hemispatial neglect with that of nonneurological control subjects. To determine the spatial coordinate system(s) used to define left and right, eye movements were measured for targets that appeared at 58,108, and 158 to the relative left or right defined with respect to the midline of the eyes, head, or midsaggital plane of the trunk. In the baseline condition, in which the various egocentric midlines were all aligned with the environmental midline, patients were disproportionately slower at initiating saccades to left than right targets, relative to the controls. When either the trunk or the head was rotated and the midline aligned with the most peripheral position while the eyes remained aligned with the midline of the environment, the results did not differ from the baseline condition. However, when the eyes were rotated and the midline aligned with the peripheral position, saccadic reaction time (SRT) differed significantly from the baseline, especially when the eyes were rotated to the right. These findings suggest that target position is coded relative to the current position of gaze (oculocentrically) and that this eye-centered coding is modulated by orbital position (eye-in-head signal). The findings dovetail well with results from existing neurophysiological studies and shed further light on the spatial representations mediated by the human parietal cortex.
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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DOI：
10.1037//0096-1523.25.1.83
发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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