NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells.
NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells.
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DOI：
10.3389/fimmu.2014.00192
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发表时间：
2014
影响因子：
7.3
通讯作者：
López-Vergès S
中科院分区：
文献类型：
--
作者：
Beltrán D;López-Vergès S
除了B-和T-细胞应答之外，先天免疫应答在针对登革病毒（DENV）感染和疾病严重程度的保护中起作用。自然杀伤（NK）细胞的早期激活和I型干扰素依赖性免疫可能在DENV感染的早期阶段限制病毒复制并因此减少随后的发病机制中是重要的。NK细胞还可以产生减少炎症和组织损伤的细胞因子。另一方面，NK细胞也能够在DENV感染的早期时间点诱导肝损伤。在体外，NK细胞可以通过抗体依赖性细胞介导的细胞毒性杀死抗体包被的DENV感染的细胞。此外，NK细胞可以通过其活化受体直接识别DENV感染的细胞，尽管HLA I类表达的增加可能允许感染的细胞逃避NK应答。最近，全基因组关联研究已经显示MICB和云母（其编码活化NK受体NKG 2D的配体）与登革热疾病结果之间的关联。本文综述了NK细胞对DENV感染细胞的识别以及DENV对NK细胞配体表达的调控。
The innate immune response, in addition to the B- and T-cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of natural killer (NK) cells and type-I interferon-dependent immunity may be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENV-infected cells through antibody-dependent cell-mediated cytotoxicity. In addition, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome. This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.
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影响因子：
5.4
作者：
KURANE, I;HEBBLEWAITE, D;ENNIS, FA
通讯作者：
ENNIS, FA
影响因子：
5.4
作者：
Hershkovitz, Oren;Zilka, Alon;Porgador, Angel
通讯作者：
Porgador, Angel
DOI：
10.1086/590117
发表时间：
2008-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chau TN;Quyen NT;Thuy TT;Tuan NM;Hoang DM;Dung NT;Lien le B;Quy NT;Hieu NT;Hieu LT;Hien TT;Hung NT;Farrar J;Simmons CP
通讯作者：
Simmons CP
影响因子：
20.3
作者：
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通讯作者：
Long, EO
影响因子：
5.4
作者：
Guabiraba, Rodrigo;Besnard, Anne-Gaelle;Teixeira, Mauro M.
通讯作者：
Teixeira, Mauro M.