Association between Serum 25-Hydroxy Vitamin D Levels and the Prevalence of Adult-Onset Asthma.
Association between Serum 25-Hydroxy Vitamin D Levels and the Prevalence of Adult-Onset Asthma.
复制标题
DOI：
10.3390/ijerph15061103
复制
发表时间：
2018-05-29
影响因子：
--
通讯作者：
Osborne NJ
中科院分区：
文献类型：
--
作者：
Cherrie MPC;Sarran C;Osborne NJ
维生素D(25(OH)D)的主要循环代谢产物与特应性皮炎、哮喘和其他过敏性疾病的发病机制有关，这些疾病具有下游的免疫调节作用。然而，在观察性研究中，25(OH)D和成年期哮喘之间的一致联系尚未被发现。我们的目标是测试25(OH)D与成年期哮喘的关联，并假设这种关联在非特应性参与者中会更强。利用收集的1958年出生队列参与者的信息，我们开发了一种新的测量特应性状态的方法，使用总的和特定的IgE值以及报告的湿疹和过敏性鼻炎病史。我们设计了一项嵌套式病例对照分析，按特应性状态分层，并使用Logistic回归模型调查了46岁时测量的25(OH)D与50岁时哮喘和喘息性支气管炎患病率之间的关系，排除了42岁之前报告患有哮喘或喘息性支气管炎的参与者。在完全调整的模型中，血清25(OH)D患病率升高10nmol/L与哮喘显著相关(AOR0.94；95%CI 0.88~1.00)。有一些证据表明，25(OH)D水平与哮喘之间的联系存在特应性依赖趋势。关于变态反应状态可操作性的进一步分析工作将有助于揭示25(OH)D和其他哮喘危险因素是否存在作用。
The major circulating metabolite of vitamin D (25(OH)D) has been implicated in the pathogenesis for atopic dermatitis, asthma and other allergic diseases due to downstream immunomodulatory effects. However, a consistent association between 25(OH)D and asthma during adulthood has yet to be found in observational studies. We aimed to test the association between 25(OH)D and asthma during adulthood and hypothesised that this association would be stronger in non-atopic participants. Using information collected on the participants of the 1958 birth cohort, we developed a novel measure of atopic status using total and specific IgE values and reported history of eczema and allergic rhinitis. We designed a nested case-control analysis, stratified by atopic status, and using logistic regression models investigated the association between 25(OH)D measured at age 46 years with the prevalence of asthma and wheezy bronchitis at age 50 years, excluding participants who reported ever having asthma or wheezy bronchitis before the age of 42. In the fully adjusted models, a 10 nmol/L increase in serum 25(OH)D prevalence had a significant association with asthma (aOR 0.94; 95% CI 0.88–1.00). There was some evidence of an atopic dependent trend in the association between 25(OH)D levels and asthma. Further analytical work on the operationalisation of atopy status would prove useful to uncover whether there is a role for 25(OH)D and other risk factors for asthma.
登录
查看更多内容
影响因子：
13.6
作者：
Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth
影响因子：
12.4
作者：
Confino-Cohen, R.;Brufman, I.;Feldman, B. S.
通讯作者：
Feldman, B. S.
影响因子：
6.1
作者：
Hirai, K.;Shirai, T.;Itoh, K.
通讯作者：
Itoh, K.
影响因子：
14.2
作者：
de Groot, Jantina C.;van Roon, Eric N. H.;ten Brinke, Anneke
通讯作者：
ten Brinke, Anneke
影响因子：
12.4
作者：
Anto, J. M.;Sunyer, J.;Burney, P.
通讯作者：
Burney, P.