Fetal and infant origins of asthma.
Fetal and infant origins of asthma.
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DOI：
10.1007/s10654-012-9657-y
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发表时间：
2012-01
影响因子：
13.6
通讯作者：
Duijts, Liesbeth
中科院分区：
文献类型：
--
作者：
Duijts, Liesbeth
关键词：
以前的研究表明，哮喘和其他常见疾病一样，至少有一部分起源于生命早期。低出生体重已被证明与成人哮喘、慢性阻塞性气道疾病和肺功能受损的风险增加以及儿童早期呼吸道症状的风险增加有关。发育可塑性假说认为，低出生体重和以后生活中的疾病之间的关联可以通过胎儿和婴儿期对各种不利暴露的适应机制来解释。已经研究了胎儿和婴儿不良暴露导致生长适应和呼吸健康结果的各种途径，包括胎儿和早期婴儿生长模式、母亲吸烟和饮食、儿童饮食、呼吸道感染和对乙酰氨基酚使用以及遗传易感性。然而，胎儿和出生后早期的特定有害暴露导致成人呼吸道疾病的情况尚未完全了解。目前的研究表明，在生命的各个阶段的环境和遗传因素，以及他们的表观遗传机制可能是低出生体重与呼吸系统疾病在以后的生活复杂的关联。需要新的精心设计的流行病学研究来确定具体的潜在机制。这篇综述集中在特定的不利胎儿和婴儿的生长模式和暴露，遗传易感性，可能的呼吸适应和新的研究前景。
Previous studies have suggested that asthma, like other common diseases, has at least part of its origin early in life. Low birth weight has been shown to be associated with increased risks of asthma, chronic obstructive airway disease, and impaired lung function in adults, and increased risks of respiratory symptoms in early childhood. The developmental plasticity hypothesis suggests that the associations between low birth weight and diseases in later life are explained by adaptation mechanisms in fetal life and infancy in response to various adverse exposures. Various pathways leading from adverse fetal and infant exposures to growth adaptations and respiratory health outcomes have been studied, including fetal and early infant growth patterns, maternal smoking and diet, children’s diet, respiratory tract infections and acetaminophen use, and genetic susceptibility. Still, the specific adverse exposures in fetal and early postnatal life leading to respiratory disease in adult life are not yet fully understood. Current studies suggest that both environmental and genetic factors in various periods of life, and their epigenetic mechanisms may underlie the complex associations of low birth weight with respiratory disease in later life. New well-designed epidemiological studies are needed to identify the specific underlying mechanisms. This review is focused on specific adverse fetal and infant growth patterns and exposures, genetic susceptibility, possible respiratory adaptations and perspectives for new studies.
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影响因子：
13.6
作者：
Alatupa, Saija;Pulkki-Raback, Laura;Keltikangas-Jarvinen, Liisa
通讯作者：
Keltikangas-Jarvinen, Liisa
DOI：
10.1164/rccm.201005-0757oc
发表时间：
2011-01-15
影响因子：
24.7
作者：
Beasley, Richard W.;Clayton, Tadd O.;Stewart, Alistair W.
通讯作者：
Stewart, Alistair W.
影响因子：
8.3
作者：
Brion, Marie-Jo A.;Leary, Sam D.;Ness, Andy R.
通讯作者：
Ness, Andy R.
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
158.5
作者：
Bouzigon, Emmanuelle;Corda, Eve;Demenais, Florence
通讯作者：
Demenais, Florence