Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects.
Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects.
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DOI：
10.3390/nu10081011
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发表时间：
2018-08-03
期刊：
影响因子：
5.9
通讯作者：
Jalal DI
中科院分区：
文献类型：
--
作者：
Kuwabara M;Kuwabara R;Niwa K;Hisatome I;Smits G;Roncal-Jimenez CA;MacLean PS;Yracheta JM;Ohno M;Lanaspa MA;Johnson RJ;Jalal DI
肥胖是高血压、糖尿病（DM）、血脂异常和高尿酸血症的危险因素。在这里，我们评估了美国人口相同的体重指数（BMI）是否会在日本产生类似的代谢风险。这是一项涉及90，047名日本成年人的横断面分析（18-85岁）和14，734名来自美国国家健康和营养检查调查（NHANES）的成年人。我们根据日本和美国的BMI比较了高血压、DM、血脂异常和高尿酸血症的患病率。和血脂异常的患病率在美国显著高于日本，而高尿酸血症的患病率在不同国家之间没有差异。在调整了年龄、性别、吸烟和饮酒习惯、慢性肾脏疾病和其他心血管危险因素后，在日本和美国，较高的BMI是高血压、DM、血脂异常和高尿酸血症的独立危险因素。在美国，这些心脏代谢风险因素患病率增加的BMI临界值显著高于日本（高血压为27与23 kg/m2，DM为29与23 kg/m2，血脂异常为26与22 kg/m2，高尿酸血症为27与23 kg/m2）。在日本和美国，较高的BMI与高血压、DM、血脂异常和高尿酸血症的患病率增加相关。日本的BMI临界值（高于此临界值时，心脏代谢危险因素的患病率增加）显著低于美国，这表明超重/肥胖的相同定义可能不适用于这两个国家。
Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia. Here, we evaluated whether the same body mass index (BMI) for the U.S. population conferred similar metabolic risk in Japan. This was a cross-sectional analysis involving 90,047 Japanese adults (18–85 years) from St. Luke’s International Hospital, Tokyo, Japan and 14,734 adults from National Health and Nutrition Examination Survey (NHANES) collected in the U.S. We compared the prevalence of hypertension, DM, dyslipidemia, and hyperuricemia according to BMI in Japan and the U.S. The prevalence of hypertension, DM, and dyslipidemia were significantly higher in the U.S. than Japan, whereas the prevalence of hyperuricemia did not differ between countries. Higher BMI was an independent risk factor for hypertension, DM, dyslipidemia, and hyperuricemia both in Japan and in the U.S. after adjusting for age, sex, smoking and drinking habits, chronic kidney disease, and other cardiovascular risk factors. The BMI cut-off above which the prevalence of these cardio-metabolic risk factors increased was significantly higher in the U.S. than in Japan (27 vs. 23 kg/m2 for hypertension, 29 vs. 23 kg/m2 for DM, 26 vs. 22 kg/m2 for dyslipidemia, and 27 vs. 23 kg/m2 for hyperuricemia). Higher BMI is associated with an increased prevalence of hypertension, DM, dyslipidemia, and hyperuricemia both in Japan and U.S. The BMI cut-off above which the prevalence of cardio-metabolic risk factors increases is significantly lower in Japan than the U.S., suggesting that the same definition of overweight/obesity may not be similarly applicable in both countries.
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自1980年以来，糖尿病的全球趋势：对751个基于人群的研究的共同分析，有440万参与者。
DOI：
10.1016/s0140-6736(16)00618-8
发表时间：
2016-04-09
期刊：
Lancet (London, England)
影响因子：
--
作者：
NCD Risk Factor Collaboration (NCD-RisC)
通讯作者：
NCD Risk Factor Collaboration (NCD-RisC)
影响因子：
3.5
作者：
Kuwabara, Masanari;Niwa, Koichiro;Hisatome, Ichiro
通讯作者：
Hisatome, Ichiro
DOI：
10.1016/s0002-8223(99)00016-4
发表时间：
1999-01-01
影响因子：
--
作者：
Pan, YL;Dixon, Z;Huffman, F
通讯作者：
Huffman, F
影响因子：
7.1
作者：
Sugano, M;Hirahara, F
通讯作者：
Hirahara, F
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira